Guesthouse vacation rentals in James Island
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Top-rated guesthouse rentals in James Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for James Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
Oct 7 – 14
Guesthouse in Charleston
4.93 out of 5 average rating, 317 reviewsCozy Island Cottage
Apr 23 – 30
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 214 reviewsBungalow Under The Oaks
Sep 21 – 28
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Jul 12 – 19
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
Jan 10 – 17
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 220 reviewsGreen Garden Studio @greengardenstudio2017
Oct 1 – 8
Guesthouse in Johns Island
4.98 out of 5 average rating, 239 reviewsPrivate waterfront apt in the oaks
Sep 15 – 22
Guesthouse in Charleston
4.84 out of 5 average rating, 110 reviewsRomantic Beach Style Cottage close to everything!
Dec 19 – 26
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Oct 24 – 31
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Dec 22 – 29
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Oct 2 – 9
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Jan 17 – 24
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
Jul 8 – 15
Guesthouse in Charleston
5.0 out of 5 average rating, 13 reviewsGas Light Carriage House James Island
Aug 13 – 20
Guesthouse in Charleston
4.82 out of 5 average rating, 93 reviewsGuest Suite by the Beach
Aug 28 – Sep 4
Guesthouse in Charleston
5.0 out of 5 average rating, 32 reviewsCharleston Beach Getaway
Nov 17 – 24
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.99 out of 5 average rating, 142 reviewsLarge Guesthouse with Private Dock & Marsh Views
Oct 16 – 23
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 407 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Dec 26 – Jan 2
Guesthouse in Charleston
4.98 out of 5 average rating, 108 reviewsCharleston Casita near Folly Beach *Dog Friendly*
Jun 13 – 20
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Nov 19 – 26
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 222 reviewsCozy Apartment in Mount Pleasant
Dec 15 – 22
Guesthouse in Charleston
4.9 out of 5 average rating, 548 reviewsCute, Cozy, Charleston Cottage
Sep 12 – 19
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Nov 2 – 9
Guesthouse in Charleston
4.99 out of 5 average rating, 206 reviewsRedesigned suite! 12min to city, pet-friendly
Sep 30 – Oct 7
Destinations to explore
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- Villa rentals James Island
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