Guesthouse vacation rentals in South Carolina
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Greenville
4.92 out of 5 average rating, 582 reviewsHistoric 19th Century Cabin/Guest House
Feb 8 – 15
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 219 reviewsPrivate Studio Apt - (Pets/beach/pool/golf)
Sep 22 – 29
Guesthouse in Townville
4.88 out of 5 average rating, 230 reviewsLisa’s Lodge
May 27 – Jun 3
Guesthouse in Charleston
4.92 out of 5 average rating, 302 reviewsMother in Law in James Island Riverland Terrace
Jan 21 – 28
Guesthouse in Camden
4.94 out of 5 average rating, 179 reviewsRed Roof Loft @ FireFly Farm
Oct 3 – 10
Guesthouse in Bluffton
4.98 out of 5 average rating, 355 reviewsHickory Trace Carriage House
Sep 18 – 25
Guesthouse in Ridgeville
4.82 out of 5 average rating, 213 reviewsPond House Bungalow at Natural Gathering Grounds
Aug 26 – Sep 2
Guesthouse in Donalds
4.99 out of 5 average rating, 344 reviewsHome on the farm
Dec 25 – Jan 1
Guest house rentals with a patio
Guesthouse in Fort Mill
4.96 out of 5 average rating, 134 reviewsCarriage House Suite on Lake Wylie
Oct 18 – 25
Guesthouse in Charleston
4.93 out of 5 average rating, 172 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Jan 6 – 13
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Oct 2 – 9
Guesthouse in Columbia
4.95 out of 5 average rating, 148 reviewsRenovated One Bedroom Guest House by UofSC
Sep 27 – Oct 4
Guesthouse in North Charleston
5.0 out of 5 average rating, 111 reviewsThe Park Circle Clerestory Studio Guest House
Jun 19 – 26
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Oct 24 – 31
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Dec 22 – 29
Guesthouse in Spartanburg
5.0 out of 5 average rating, 39 reviewsThe Lodge at Pythian Park
Oct 16 – 23
Guest house rentals with a washer and dryer
Guesthouse in Abbeville
4.99 out of 5 average rating, 148 reviewsModern Carriage House
Jun 4 – 11
Guesthouse in Lyman
4.99 out of 5 average rating, 123 reviewsBlue Heron Hideaway Lakeside Retreat
Jul 11 – 18
Guesthouse in Florence
4.92 out of 5 average rating, 126 reviewsMidtown Retreat - Guest House in heart of Florence
Jul 3 – 10
Guesthouse in Saint Helena Island
4.99 out of 5 average rating, 188 reviewsCharming Waterfront Cottage with Beautiful Views.
Aug 26 – Sep 2
Guesthouse in Florence
4.99 out of 5 average rating, 666 reviewsBoho Private Downtown Stay Near I-95 & Hospital
Jul 15 – 22
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 407 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Dec 26 – Jan 2
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
Oct 7 – 14
Guesthouse in Bluffton
4.96 out of 5 average rating, 325 reviewsOld Town Bluffton Carriage Apt.
Nov 25 – Dec 2
Destinations to explore
- House rentals United States
- Guesthouse rentals United States
- Ski-in/ski-out rentals South Carolina
- Rentals with an accessible height bed South Carolina
- Lakehouse rentals South Carolina
- Rentals with a patio South Carolina
- Rentals with a sauna South Carolina
- Rentals with outdoor seating South Carolina
- Beach house rentals South Carolina
- Kid-friendly rentals South Carolina
- Rentals with beach access South Carolina
- Beachfront rentals South Carolina
- Rentals with breakfast South Carolina
- Condo rentals South Carolina
- Rentals with a kayak South Carolina
- Cottage rentals South Carolina
- Resort rentals South Carolina
- Beach condo rentals South Carolina
- Apartment rentals South Carolina
- Rentals with a fire pit South Carolina
- Loft rentals South Carolina
- Luxury rentals South Carolina
- Campsite rentals South Carolina
- Townhouse rentals South Carolina
- Monthly Rentals South Carolina
- Farmstay rentals South Carolina
- Rentals with a home theater South Carolina
- Pet-friendly rentals South Carolina
- Bed and breakfasts South Carolina
- Aparthotel rentals South Carolina
- House rentals South Carolina
- RV rentals South Carolina
- Hostel rentals South Carolina
- Rentals with a washer and dryer South Carolina
- Boutique hotel rentals South Carolina
- Rentals with an EV charger South Carolina
- Fitness-friendly rentals South Carolina
- Cabin rentals South Carolina
- Villa rentals South Carolina
- Family-friendly rentals South Carolina
- Rentals with a hot tub South Carolina
- Rentals with a fireplace South Carolina
- Rentals with pools South Carolina
- Waterfront rentals South Carolina
- Hotel rentals South Carolina
- Rentals with lake access South Carolina
- Rentals with an accessible height toilet South Carolina
- Serviced apartment rentals South Carolina
- Bungalow rentals South Carolina
- Tiny house rentals South Carolina
- Private suite rentals South Carolina
- Smoking-friendly rentals South Carolina
- Wheelchair accessible rentals South Carolina
- House rentals Charlotte
- Guesthouse rentals Charlotte
- House rentals Greenville
- Guesthouse rentals Greenville
- Guesthouse rentals Columbia
- House rentals Columbia
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom