Guesthouse vacation rentals in Charleston

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Charleston

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Guesthouse in James Island

5 out of 5 average rating, 156 reviews

The Guesthouse at Old Orchard

Relax in the treetops of our beautiful pecan grove! Guests adore the peaceful surroundings of our new 1260 sq ft guesthouse located on the second floor of a detached garage. This private space has an open floor plan, fully stocked kitchen, 2 queen bedrooms, 2 full baths, wifi, Roku TVs, and new appliances including washer and dryer. Sitting on 1.3 acres, the property is home to gardens, a tidal creek, and happy hens! It is quiet yet centrally located between downtown Charleston and Folly Beach.

Guest favorite

Guesthouse in Summerville

4.98 out of 5 average rating, 669 reviews

★Delightful guest house near historic plantations★

Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*

Guest favorite

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 208 reviews

Charleston Guesthouse

Conveniently nestled in the heart of Mt. Pleasant and only a short car ride from the best that Charleston has to offer. Minutes away from historic sites such as Boone Hall Plantation, Palmetto Island County Park, Belle Hall shopping center and many other attractions. Centrally located between Isle of Palms/Sullivan's beaches and downtown Charleston. Located in a peaceful, family friendly community reminiscent of old country living. Sit back and enjoy the quietness of your home away from home.

Guest favorite

Guesthouse in James Island

4.96 out of 5 average rating, 257 reviews

Unique Hidden Gem w/ Luxury Shower Near Beach & DT

Drive down a charming dirt road, to a wooded setting w/ privacy: our 2 bedroom, 2 story guesthouse provides a huge shower that our guests love! Not your basic Airbnb: Enjoy time off the beaten path! DOORS GALORE: industrial style living area includes ✔ kitchen ✔washer/dryer ✔TV ✔small dining table - a quiet place, few miles from DTN and Folly Beach. Our hidden gem gives a tucked away vibe, but still close to Charleston's hot spots! We can't wait to host you! Click below for more info/details!

Guest favorite

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 113 reviews

5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!

The Treehouse is a private, cozy, modern retreat in the hippest area of Mt. Pleasant - right between downtown & the beaches for easy access to both. Located less than 5 mi. from Sullivan's Island, less than 2 mi. from the Cooper River Bridge (to downtown Charleston), and just a short walk from Shem Creek, you won't find a better place to stay in the Holy City. *Minimum age required to rent: 21 years old. Children welcome with adult accompaniment.*STR PERMIT #: ST240234 SC BUS. LIC #: 20104817

Guest favorite

Guesthouse in James Island

4.91 out of 5 average rating, 180 reviews

Riverland Terrace Guesthouse

Private and quiet guest suite perfect for nature lovers. Our guest house is tucked up against a small marshy area in our backyard on James Island. Located about 5 minutes to downtown Charleston, 5 minutes to John's Island and 15 minutes to Folly Beach. Five minute walk to the Pour House and all terrace area restaurants and the terrace theater. We are a very laid back couple looking for laid back guests who need a quiet and peaceful place to use as their base while exploring Charleston.

Guest favorite

Guesthouse in West Ashley

5 out of 5 average rating, 100 reviews

Liz Lane Cottage- entire guesthouse

Our brand new guest house is a spacious one bedroom, one bath with a bunk loft. Come enjoy our quiet neighborhood after a full day of sightseeing. Located 2 miles from downtown, 10 miles from Folly beach or Sullivan’s island, this tastefully decorated guest house will not disappoint! Guests will have access to the entire cottage. The backyard is shared with the main house.This quaint West Ashley neighborhood is seated in between downtown and the trendy shops of Avondale. STR permit #04191

Guest favorite

Guesthouse in West Ashley

4.97 out of 5 average rating, 148 reviews

Studio Apartment Minutes to Downtown Charleston

Welcome to our adorable studio apartment located close to all Charleston has to offer. A short 5 minute drive will land you in the heart of downtown Charleston. If it's the beach you are looking for, we are located between Folly Beach(12 minutes) and Sullivans Island(15 minutes). The guesthouse is also walking distance to many shops, restaurants, bars and an organic grocery store. Enjoy a morning walk or bike ride on the Greenway that backs up to the property spanning 16 miles roundtrip.

Guest favorite

Guesthouse in West Ashley

4.97 out of 5 average rating, 260 reviews

Urban Oasis, West of the Ashley

Private, renovated guesthouse in a quiet neighborhood. Studio includes everything needed for a short or long stay, including a kitchen with a stove and microwave for cooking, seating area to relax, and beautiful deck to enjoy the outdoors. Separate entryway and fenced in area for ultimate privacy. Convenient to all the charm Charleston offers, including: 5 miles to downtown, biking distance to great restaurants and bars, 12 miles to Folly Beach and 14 miles to Sullivan's Island.

Guest favorite

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 233 reviews

Bungalow Under The Oaks

Small guest house in the heart of Mount Pleasant! Ideally located to both Isle of Palms and Sullivan's Island beaches (both 7 minutes) and only 15 minutes to the heart of historic downtown Charleston. Our private guest bungalow is a perfect launching spot for all your exploring. End the day relaxing under the shade of our mature live oak. The house has its own entrance and separate yard that is fully fenced in. LHR Permit: ZSTR-02-21-00318, License: LIC-3-21-252314.

Guest favorite

Guesthouse in West Ashley

4.98 out of 5 average rating, 146 reviews

Private Backyard With Fire Pit, 15 Min to Downtown

Welcome to this newly renovated guesthouse in the heart of West Ashley. While staying in this adorable 850 sqft. home, you'll fall in love with the newly redone kitchen featuring a cozy breakfast nook. You'll also enjoy: Deck with outdoor table & chairs Free Laundry Smart TVs in all rooms Fully stocked and equipped kitchen Extremely safe neighborhood Free Parking You are only: 10 mins to Avondale 15 mins to Downtown Charleston 30 mins to Folly Beach

Guest favorite

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 433 reviews

Guesthouse Convenient to Charleston, Shem Creek, and Beaches

Relax in this separate guest home nestled in a well-established Lowcountry neighborhood. The ‘treehouse’ has an open-plan design with vaulted notched board ceilings, creating a feeling of light and space, with elegant furnishings throughout. The well-equipped kitchen and grill on the porch encourages intimate home cooking. We lived in this space before we moved into the main house, so we can attest to it being comfortable, and well maintained.