Guesthouse vacation rentals in Charleston County

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Top-rated guesthouse rentals in Charleston County

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Guest favorite

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 222 reviews

Cozy Apartment in Mount Pleasant

Our place is a cozy and bright garage apartment. It has one bedroom, living room with sleeper sofa, a full bath with tub and fully equipped kitchen. We hope this provides that home away from home feel in a relaxed, yet inviting setting. It is close to dining, the beach and a ten minute ride across the bridge to Charleston. You’ll love our place because of the coziness and the location. Our place is good for couples, solo adventurers, and business travelers. STRPermit# ST240232 SCBUSLIC#20122393

Sep 23 – 30

$119 per night

Guest favorite

Guesthouse in Charleston

4.93 out of 5 average rating, 708 reviews

Charleston's Coolest Neighborhood

You can't beat the location! You'll be 5-10 minutes from downtown Charleston, but with free off-street parking, AND you can walk to dozens of bars, restaurants, coffee shops, etc. Avondale is Central to all parts of Charleston, and its a cinch to drive to everywhere from here. This studio apartment is private, modern, and newly renovated. You'll have a kitchenette, grill, outdoor seating, and access to beach equipment. Also only a 5 minute walk to the West Ashley Greenway for biking/jogging!

Aug 5 – 12

$138 per night

Guest favorite

Guesthouse in Charleston

4.93 out of 5 average rating, 171 reviews

Quaint Cottage Studio in Ashley Forest (Avondale)

Take in the peace, calm, and hospitality of Charleston at this small, quaint, stand-alone cottage. The studio is situated on our property and shares an outdoor lounge and dining area. Located in the neighborhood of Ashley Forest, a small corner of Avondale, you are walking distance to breweries, cafes, wine bars, sushi restaurants and more. Downtown is a 10 minute ride share away, and there is also a bus stop five minutes from the property that will take you to the heart of King Street.

Mar 28 – Apr 4

$114 per night

Guest favorite

Guesthouse in Charleston

4.91 out of 5 average rating, 126 reviews

Centerville Loft, Studio Apt on James Island

Welcome to the Centerville loft. They don't call it Centerville for nothing! This space is in a quiet neighborhood at the center of James Island 4–5 miles from Downtown Charleston and 6 miles from Folly beach. This property is a back yard studio apt with a small kitchenette with microwave, mini fridge, Keurig coffeemaker, magic bullet smoothie blender, 32” TV, record player with records, bluetooth, and a patio. We are within walking distance to several restaurants along Folly road.

Aug 13 – 20

$120 per night

Guest favorite

Guesthouse in Charleston

4.97 out of 5 average rating, 243 reviews

Urban Oasis, West of the Ashley

Private, renovated guesthouse in a quiet neighborhood. Studio includes everything needed for a short or long stay, including a kitchen with a stove and microwave for cooking, seating area to relax, and beautiful deck to enjoy the outdoors. Separate entryway and fenced in area for ultimate privacy. Convenient to all the charm Charleston offers, including: 5 miles to downtown, biking distance to great restaurants and bars, 12 miles to Folly Beach and 14 miles to Sullivan's Island.

Jun 21 – 28

$129 per night

Guest favorite

Guesthouse in Charleston

4.98 out of 5 average rating, 244 reviews

Detached Guest Suite

Detached guest suite( 45" Smart TV )with full bath. Outdoor space, including pool , outdoor kitchen(microwave,fridge , gas cook top,Keurig with coffeepods,cream,sugar,Toaster oven) and gas fireplace with large screen Smart TV . Separate entrance .14 miles to airport(appx. 20 mins) 10 miles to downtown , Beaches(Kiawah appx. 24 miles or Folly 16 miles ). The pool is shared with the owners but our guests are given plenty of privacy. Operation Permit #OP2023-04522

Jan 6 – 13

$116 per night

Guest favorite

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 214 reviews

Bungalow Under The Oaks

Small guest house in the heart of Mount Pleasant! Ideally located to both Isle of Palms and Sullivan's Island beaches (both 7 minutes) and only 15 minutes to the heart of historic downtown Charleston. Our private guest bungalow is a perfect launching spot for all your exploring. End the day relaxing under the shade of our mature live oak. The house has its own entrance and separate yard that is fully fenced in. LHR Permit: ZSTR-02-21-00318, License: LIC-3-21-252314.

Sep 21 – 28

$141 per night

Guest favorite

Guesthouse in Charleston

4.97 out of 5 average rating, 333 reviews

Daniel Island Getaway

Welcome to your home away from home near Center Park on Daniel Island, located within 20 minutes from Downtown Charleston, Sullivan’s Island and Isle of Palms. This almost 600sqft above garage guest house has a separate bedroom and full bathroom in addition to a spacious living room with a Queen sofa bed and a kitchen area that will meet all of your basic needs. The kitchen includes a Keurig, microwave and griddle. There is even an outdoor shower for guests to use.

Aug 16 – 23

$115 per night

Guest favorite

Guesthouse in Charleston

5.0 out of 5 average rating, 216 reviews

James Island "La Casita" Nestled btw Beach & City

Wake up to the 2 grand oaks just outside your window. Visit Folly Beach (14 minutes) or Historic Downtown Charleston (9 minutes). Craft your own meal in the complete kitchen or try one of the many renowned Charleston restaurants recognized by foodies worldwide. Visit James Island County Park & Waterpark (1 mile). Take a trip to the local Farmer's Market or the Municipal Golf Club. Then stroll down the (Woodland Shores) road for a spectacular view of the wetlands.

Aug 19 – 26

$143 per night

Guest favorite

Guesthouse in North Charleston

4.93 out of 5 average rating, 723 reviews

Boho Converted Garage Apt. - Cozy & Convenient!

Stay in centrally located Park Circle for a charming Charleston experience you won't get downtown! * 1-2 minute walk to Park Circle restaurants and bars * 10-minute drive from the Charleston International Airport * 10-20 minute drive to Historic Downtown Charleston * 30-minute drive to local beaches - Drives times are assuming traffic isn't awful! It can get bad during peak seasons, but the point is, we are very centrally located in the Charleston area!

Aug 12 – 19

$96 per night

Guest favorite

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 406 reviews

Guesthouse Convenient to Charleston, Shem Creek, and Beaches

Relax in this separate guest home nestled in a well-established Lowcountry neighborhood. The ‘treehouse’ has an open-plan design with vaulted notched board ceilings, creating a feeling of light and space, with elegant furnishings throughout. The well-equipped kitchen and grill on the porch encourages intimate home cooking. We lived in this space before we moved into the main house, so we can attest to it being comfortable, and well maintained.

Feb 10 – 17

$143 per night

Guest favorite

Guesthouse in Summerville

4.97 out of 5 average rating, 216 reviews

Tiny Oak Cottage in Historic Downtown Summerville

This unique tiny home styled cottage is nestled in the heart of Summerville´s downtown Historic district and boasts completely updated modern amenities to make your stay in our charming hometown a time to remember. You’ll be within easy walking distance of numerous shops, restaurants, and the world famous Sweet Tea mug, but also only 22 miles from the Holy City of Charleston or your pick of our many islands and beaches that dot the Lowcounty.

Nov 27 – Dec 4

$97 per night