Villa vacation rentals in James Island
Find and book unique villas on Airbnb
Top-rated villa rentals in James Island
Guests agree: these villas are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for James Island villa rentals
Private villa rentals
Villa in Kiawah Island
4.97 out of 5 average rating, 88 reviewsLagoon view villa with office, easy walk to beach!
Oct 15 – 22
Villa in Seabrook Island
4.91 out of 5 average rating, 11 reviewsLuxury Seabrook Isl Beach Condo
Dec 17 – 24
Villa in Kiawah Island
4.93 out of 5 average rating, 96 reviewsClean & Comfortable! Steps to the beach!
May 12 – 19
Villa in Seabrook Island
4.83 out of 5 average rating, 59 reviewsPrivate island villa with luxury resort amenities!
Nov 2 – 9
Villa in Seabrook Island
4.9 out of 5 average rating, 31 reviewsUpscale Villa, Amenity Included! Dog Friendly
Jan 26 – Feb 2
Villa in Seabrook Island
4.85 out of 5 average rating, 34 reviewsSeabrook Golf View Villa: Pickleball, Bike & Pool
Oct 24 – 31
Villa in Seabrook Island
4.92 out of 5 average rating, 52 reviewsNewly Remodeled Villa, 5 Minute Walk to Beach
Feb 28 – Mar 7
Villa in Seabrook Island
4.57 out of 5 average rating, 7 reviewsBeach and Golf Paradise | Vaughan Villa
Jan 29 – Feb 5
Luxury villa rentals
Villa in Johns Island
4.75 out of 5 average rating, 4 reviewsOceanfront! Renovated, Easiest Beach Access
Oct 12 – 19
Villa in Kiawah Island
5.0 out of 5 average rating, 26 reviewsOcean Front! Beach is steps away. Clean and Crisp!
Jul 27 – Aug 3
Villa in Isle of Palms
Surfside Villa | Oceanfront Luxury | 8 Beach Club
Apr 21 – 28
Villa in Seabrook Island
Seaside Therapy - An iTrip Vacations Home
Aug 14 – 21
Villa in Kiawah Island
5.0 out of 5 average rating, 15 reviewsOceanfront Windswept Villa
Aug 23 – 30
Villa in Isle of Palms
4.76 out of 5 average rating, 25 reviewsBeachfront IOP Villa with Outdoor Pool. Remodeled!
Sep 17 – 24
Villa in Johns Island
5.0 out of 5 average rating, 3 reviews3 Bedroom 2 Bath Duneloft Villa! Neighborhood Pool
Jul 29 – Aug 5
Villa in Kiawah Island
4.89 out of 5 average rating, 18 reviewsSpacious Penthouse 3BR 3Bath Villa with Ocean View
Nov 26 – Dec 3
Villa rentals with a pool
Villa in Edisto Island
4.95 out of 5 average rating, 22 reviewsWaves of Change
Sep 26 – Oct 3
Villa in Seabrook Island
4.96 out of 5 average rating, 56 reviewsLuxe Tropical Resort Escape - Walk to the Beach!
Sep 23 – 30
Villa in Seabrook Island
4.61 out of 5 average rating, 28 reviewsSpacious 1BR | Balcony | Pool |
Sep 1 – 8
Villa in Seabrook Island
5.0 out of 5 average rating, 5 reviewsStunning Water Views Renovated Modern Oasis
Nov 12 – 19
Villa in Isle Of Palms
4.78 out of 5 average rating, 37 reviews7C Seagrove - Sweetgrass
Feb 6 – 13
Villa in Seabrook Island
4.96 out of 5 average rating, 23 reviewsUpscale, Private,Breathtaking Views
Mar 3 – 10
Villa in Johns Island
4.73 out of 5 average rating, 26 reviewsDog friendly villa on 8th hole of golf course
Dec 27 – Jan 3
Villa in Johns Island
Tranquil 1BR in High Hammock Villas
Dec 22 – 29
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