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Guesthouse vacation rentals in Panama
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Panama
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama guesthouse rentals
Family-friendly guest house rentals
![](https://a0.muscache.com/im/pictures/7f8ffa5b-deb5-401c-bc5c-cae41da2f0d4.jpg?im_w=720)
Guesthouse in Nueva Gorgona
4.99 out of 5 average rating, 67 reviewsBeautiful Casita-Paradise in Panama, Nueva Gorgona
![](https://a0.muscache.com/im/pictures/becfcffa-674e-4104-89cd-36cc53d95eec.jpg?im_w=720)
Guesthouse in Alto Boquete
4.82 out of 5 average rating, 65 reviewsAccommodation. Sinsonte )
![](https://a0.muscache.com/im/pictures/7370d2c1-692e-45a1-b26e-ab13d9d3f02d.jpg?im_w=720)
Guesthouse in Jaramillo Arriba
4.92 out of 5 average rating, 38 reviewsCaramel house
![](https://a0.muscache.com/im/pictures/bcfc9347-0528-4400-b1b0-c7c6a4c1904b.jpg?im_w=720)
Guesthouse in Bocas del Toro Province
5 out of 5 average rating, 4 reviewsLas Palmas Casita at Bluff Beach Retreat
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Guesthouse in Boquete
5 out of 5 average rating, 9 reviewsVista a Baru
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Guesthouse in Panamá
Mochila & Art Family House
![](https://a0.muscache.com/im/pictures/0b5865d8-1904-4025-872b-47a378524bb7.jpg?im_w=720)
Private room in Panamá
4.92 out of 5 average rating, 39 reviewsPrivate cabin and CasaMomote River, Loma Limón.
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Private room in PA
4.8 out of 5 average rating, 15 reviewsLa Rosa de Los Vientos, Pedasi, double room
Guest house rentals with a patio
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Guesthouse in El Valle de Antón
5 out of 5 average rating, 4 reviewsPrivate Suite/Studio 1-Bedroom in Paradise
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Guesthouse in Panamá
New place to stayMountainview Guest House @74
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Guesthouse in Nueva California
5 out of 5 average rating, 7 reviewsVolcano View Cottage
![](https://a0.muscache.com/im/pictures/4165b0f0-0d72-4410-99a2-acaacd26caca.jpg?im_w=720)
Guesthouse in Bocas del Toro
4.88 out of 5 average rating, 16 reviewsTiny Studio w/ pool access
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Guesthouse in Saboga
4.77 out of 5 average rating, 13 reviewsIsla Contadora - Beautiful 2 bedroom guesthouse
![](https://a0.muscache.com/im/pictures/miso/Hosting-911512295018542875/original/a2210ee5-2afe-428f-9a66-ff01d54fb173.jpeg?im_w=720)
Guesthouse in Boquete
5 out of 5 average rating, 4 reviewsCozy Garden Home W/Gazebo Overlooking Baru Volcano
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Guesthouse in San Félix District
5 out of 5 average rating, 3 reviewsPlaya Las Lajas Penthouse
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Guesthouse in Alto del Espino
5 out of 5 average rating, 3 reviewsTropical Suburban Splendor.
Guest house rentals with a washer and dryer
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Guesthouse in Panama City
4.81 out of 5 average rating, 73 reviewsEfficiency Bungalow - Metropolitan Natural Park
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Guesthouse in Nueva California
5 out of 5 average rating, 15 reviewsVolcan Cloud Forest Escape for two
![](https://a0.muscache.com/im/pictures/miso/Hosting-638989317155178210/original/dadb5433-bcdd-4274-b8e1-f9f8ae0d96c3.jpeg?im_w=720)
Guesthouse in Río Hato
4.88 out of 5 average rating, 65 reviewsSustainable Guest house with Pool in Rio Hato
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Guesthouse in Boquete District
5 out of 5 average rating, 9 reviewsDuplex 1
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Guesthouse in David
5 out of 5 average rating, 7 reviewsCozy, quiet and in an excellent location!
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Guesthouse in Los Naranjos
4.69 out of 5 average rating, 62 reviewsCabaas de Alicia 1
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Guesthouse in Boquete
4.67 out of 5 average rating, 9 reviewsCozy Studio Unit with Jawdropping Views!
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1082586240835568666/original/36ebc1a5-985b-4862-b43f-9c8df2bb2abd.jpeg?im_w=720)
Guesthouse in La Concepción
New tropical guesthouse
Destinations to explore
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