Mansion vacation rentals in Panama
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Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Home in Playa Bluff
5.0 out of 5 average rating, 15 reviewsJungle House 100m from the beach
Aug 21 – 28
Villa in Río Hato
5.0 out of 5 average rating, 38 reviewsLuxury 4BR Villa + Guesthouse & Pool @Buenaventura
Jun 30 – Jul 7
Cottage in Altos del Maria
4.93 out of 5 average rating, 96 reviewsCabin with Spectacular Mountain View
Jan 1 – 8
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Jun 18 – 25
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Aug 2 – 9
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Jul 10 – 17
Condo in Maria Chiquita
5.0 out of 5 average rating, 17 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
Jun 23 – 30
Villa in Portobelo
5.0 out of 5 average rating, 42 reviewsEntire Villa with pool in front of beach!
Apr 9 – 16
Luxury mansion rentals
Apartment in Maria Chiquita
5.0 out of 5 average rating, 5 reviews4 recamaras Playa Escondida
Nov 21 – 28
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Jul 16 – 23
Villa in Punta Chame
4.93 out of 5 average rating, 14 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Dec 3 – 10
Villa in Bocas del Toro
5.0 out of 5 average rating, 10 reviewsCasa de Mono Jungle Villa by the Beach
Jan 4 – 11
Home in San José
5.0 out of 5 average rating, 13 reviewsαlkeyler | Luxury Mini Resort 20 PERS @Punta Barco
Nov 20 – 27
Cabin in Panama
4.92 out of 5 average rating, 12 reviewsCasa de Playa Portobelo Caribe
Mar 27 – Apr 3
Villa in Río Hato
4.92 out of 5 average rating, 73 reviews(Panama) Beach house with golf course.
Aug 31 – Sep 7
Villa in Juan Gallego
4.83 out of 5 average rating, 12 reviewsFantastic Villa in KasaKai
Mar 1 – 8
Pet-friendly mansion rentals
Home in Panamá
5.0 out of 5 average rating, 7 reviewsWonderful House with Terrace and Sea View
Oct 9 – 16
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Nov 22 – 29
Villa in Costa Esmeralda
4.97 out of 5 average rating, 68 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
Jul 12 – 19
Apartment in San Carlos District
4.99 out of 5 average rating, 78 reviewsAmazing Oceanfront apartment in San Carlos
Oct 14 – 21
Villa in Costa Esmeralda
5.0 out of 5 average rating, 13 reviewsSpectacular 600-meter oceanfront beach house
Mar 28 – Apr 4
Apartment in El Chirú
4.94 out of 5 average rating, 83 reviewsBuenaventura Golf & Beach Resort Lux Apartment
May 20 – 27
Home in Provincia de Panamá Oeste
4.88 out of 5 average rating, 16 reviewsLuxurious beach front home in Veracruz
Sep 13 – 20
Home in Pedasí
4.83 out of 5 average rating, 6 reviewsOcean View From The Jungle!
May 6 – 13
Destinations to explore
- Guesthouse rentals Panama
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