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Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Luxury mansion rentals
![](https://a0.muscache.com/im/pictures/prohost-api/Hosting-885417075774649662/original/a323630a-2902-4e0f-a886-7f5df4167be0.jpeg?im_w=720)
Serviced apartment in Panama City
4.8 out of 5 average rating, 35 reviewsPenthouse deluxe, 360º views and glass pool
![](https://a0.muscache.com/im/pictures/miso/Hosting-773077880978678908/original/1878c7df-5e52-45d7-832f-36f7cd826008.jpeg?im_w=720)
Cottage in Panama City
5 out of 5 average rating, 10 reviewsHacienda La Perezosa en Cerro Azul
![](https://a0.muscache.com/im/pictures/miso/Hosting-8941660/original/373b0458-380c-46b0-b818-be68d4db3483.jpeg?im_w=720)
Home in Bocas del Toro
4.9 out of 5 average rating, 21 reviewsArchitectural Waterfront Home- "Casa Comunal"
![](https://a0.muscache.com/im/pictures/miso/Hosting-22389014/original/5967f3c0-7f70-4f80-8c4d-9484aadc93d1.jpeg?im_w=720)
Villa in Playa Venao
4.81 out of 5 average rating, 43 reviewsVilla Nomada -Barefoot Luxury Beach Front Villa
![](https://a0.muscache.com/im/pictures/9bff4c61-cd17-479e-9dfa-82cde44ed51f.jpg?im_w=720)
Rental unit in Maria Chiquita
4.95 out of 5 average rating, 22 reviewsPenthouse in Playa Escondida 4 bedrooms
![](https://a0.muscache.com/im/pictures/miso/Hosting-823934795092919068/original/b959d197-4cc0-41b7-bb7b-455a5d137b43.jpeg?im_w=720)
Villa in Punta Chame
4.93 out of 5 average rating, 15 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
![](https://a0.muscache.com/im/pictures/a972b616-b930-4ce3-adb2-efe006fbf318.jpg?im_w=720)
Villa in Río Hato
4.92 out of 5 average rating, 24 reviewsSecluded Villa in Buenaventura Golf and Resort
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Villa in Las Lajas
4.82 out of 5 average rating, 17 reviewsDonde Emy Beach House
Pet-friendly mansion rentals
![](https://a0.muscache.com/im/pictures/miso/Hosting-583270287932938775/original/b8f8104b-81d8-4c3d-89f8-c2fb7e0ba7e2.jpeg?im_w=720)
Villa in Costa Esmeralda
5 out of 5 average rating, 18 reviewsSpectacular 600-meter oceanfront beach house
![](https://a0.muscache.com/im/pictures/hosting/Hosting-U3RheVN1cHBseUxpc3Rpbmc6MTAzMzk2NTQ0NjM0OTAzOTYzNg%3D%3D/original/453b5c7c-05e6-4a20-a359-6a89eb356863.jpeg?im_w=720)
Home in Pedasí
4.88 out of 5 average rating, 8 reviewsOcean View From The Jungle!
![](https://a0.muscache.com/im/pictures/9bdf43d1-abbb-47c4-834a-7a061ecef7ca.jpg?im_w=720)
Home in Playa Malibú
4.64 out of 5 average rating, 119 reviewsoceanfront home villa in malibu
![](https://a0.muscache.com/im/pictures/bcfd8c24-8e30-42a4-aaf8-1682df371306.jpg?im_w=720)
Home in Gamboa
4.87 out of 5 average rating, 89 reviewsBirdHouse@ Gamboa Panamá Canal
![](https://a0.muscache.com/im/pictures/miso/Hosting-1017985587792513392/original/5f5a158d-1765-4ad6-b103-57a3728b8cbb.jpeg?im_w=720)
Home in San José
4.83 out of 5 average rating, 30 reviewsαlkeyler| Luxury Mini Resort for 12 @Punta Barco
![](https://a0.muscache.com/im/pictures/miso/Hosting-573736663623156402/original/38aa9205-f5fd-46bd-8686-2eef3a18359f.jpeg?im_w=720)
Rental unit in Buenaventura
5 out of 5 average rating, 73 reviewsExclusive apartment steps from the sea in Puntarena
![](https://a0.muscache.com/im/pictures/miso/Hosting-627834416916985952/original/4ffd367e-fd6b-41e4-918f-1007788de0f6.jpeg?im_w=720)
Home in Panamá
4.75 out of 5 average rating, 68 reviewsLarge Private Residence in Excellent Area
![](https://a0.muscache.com/im/pictures/hosting/Hosting-809741172674277938/original/52f44249-dfe4-4ed0-b2c0-5ceca58564bb.jpeg?im_w=720)
Home in Provincia de Panamá Oeste
4.86 out of 5 average rating, 22 reviewsLuxurious beach front home in Veracruz
Mansion rentals with a pool
![](https://a0.muscache.com/im/pictures/miso/Hosting-769016131481959207/original/b37eafdf-2e1e-4ea5-a4bb-cbf7186c16a7.jpeg?im_w=720)
Rental unit in Maria Chiquita
4.96 out of 5 average rating, 70 reviewsSpacious 4Br Beachside Getaway at Playa Escondida
![](https://a0.muscache.com/im/pictures/prohost-api/Hosting-39558635/original/a3536aa8-bc70-4051-a146-9c79fc83980b.jpeg?im_w=720)
Rental unit in Panama City
4.95 out of 5 average rating, 21 reviews22M Spectacular Penthouse New Design Oceanview
![](https://a0.muscache.com/im/pictures/8fa9b36c-3e5b-408a-aed0-ca71e5b1e7c1.jpg?im_w=720)
Condo in San Carlos District
4.95 out of 5 average rating, 39 reviewsPunta Caelo Beach Front View
![](https://a0.muscache.com/im/pictures/miso/Hosting-49498447/original/42fcc8c0-70e9-4c38-b586-86369813e75a.png?im_w=720)
Rental unit in María Chiquita
4.94 out of 5 average rating, 70 reviewsPlaya Escondida Resort & Marina
![](https://a0.muscache.com/im/pictures/miso/Hosting-973265064808996596/original/1ac7c3f2-32e6-4f49-be31-8fabece05fac.jpeg?im_w=720)
Rental unit in Maria Chiquita
5 out of 5 average rating, 13 reviewsPlaya Escondida ocean and lagoon #vacfamilia
![](https://a0.muscache.com/im/pictures/miso/Hosting-845796255090034788/original/54204d60-f5cf-4eaa-b38e-4ea92c495c1f.jpeg?im_w=720)
Rental unit in Panamá
4.96 out of 5 average rating, 23 reviews140 m2 apartment down town Panama-City
![](https://a0.muscache.com/im/pictures/6121023a-c74a-4ce3-80c2-8cfaa8917b45.jpg?im_w=720)
Home in Río Hato
4.89 out of 5 average rating, 36 reviewsCasa de las Uvas a ocean-view oasis
![](https://a0.muscache.com/im/pictures/hosting/Hosting-947323704290914054/original/f51dbdd0-d5b7-49d3-bd48-3a31189da092.jpeg?im_w=720)
Rental unit in Maria Chiquita
4.88 out of 5 average rating, 16 reviewsPlaya Escondida, luxury ocean view apartment
Destinations to explore
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