Vacation home rentals in Panama
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Top-rated vacation home rentals in Panama
Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama vacation home rentals
Family-friendly vacation home rentals
Vacation home in El Chirú
4.85 out of 5 average rating, 20 reviewsApartment in Buenaventura
Oct 11 – 18
Vacation home in La Pintada
4.38 out of 5 average rating, 16 reviewsLa Pintada Inn hotel complete for private group
Jun 6 – 11
Vacation home in Panamá
Lovely place with exclusive private pool
Apr 1 – 8
Vacation home in Juan Gallego
4.84 out of 5 average rating, 80 reviewsPebos Reef, 12 guests, Amazing views!!
Jul 29 – Aug 5
Vacation home rentals with a patio
Vacation home in Anton Valley
4.9 out of 5 average rating, 42 reviewsAdorable 2 bedroom home near India Dormida hiking
Sep 13 – 20
Vacation home in Rio Hato
4.83 out of 5 average rating, 6 reviewsOcean view studio Town Center Playa Blanca Rio Hat
Dec 10 – 17
Vacation home in Volcán
4.82 out of 5 average rating, 33 reviewsBeautiful cabin with balcony
Apr 12 – 19
Vacation home in Las Escobas del Venado
4.82 out of 5 average rating, 55 reviews3 BR Family Surf Villa - Benow in Playa Venao
Dec 16 – 23
Vacation home in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPlaya Escondida, Apt with Spectacular Ocean View
Jun 9 – 16
Vacation home in San Carlos
4.87 out of 5 average rating, 31 reviewsWelcome to our house in Playa Corona
Aug 10 – 17
Vacation home in Maria Chiquita
5.0 out of 5 average rating, 6 reviewsPlaya Escondida: condo ocean view 3 bedrooms
Jun 7 – 14
Vacation home in San Carlos
5.0 out of 5 average rating, 6 reviewsSpectacular three-bedroom beach friendly
Oct 20 – 27
Vacation home rentals with a washer and dryer
Vacation home in Maria Chiquita
4.86 out of 5 average rating, 29 reviewsDreamy, Modern Caribbean Home at Playa Escondida
Aug 2 – 9
Vacation home in Maria Chiquita
5.0 out of 5 average rating, 14 reviewsPlaya Escondida, Ocean View
Jun 24 – Jul 1
Vacation home in Maria Chiquita
4.91 out of 5 average rating, 35 reviewsEntire Aparment Playa Escondida Resort &Marina
Jul 25 – Aug 1
Vacation home in San Carlos
5.0 out of 5 average rating, 28 reviewsOcean front apartment in Punta Caelo
Dec 13 – 20
Vacation home in Chitré
4.97 out of 5 average rating, 34 reviewsCASA EdditA ° Cozy house in Chitre
Jan 9 – 16
Vacation home in Bajo Boquete
4.7 out of 5 average rating, 23 reviewsRio Verde: Splendid suite w/ hammock & river view
Aug 31 – Sep 7
Vacation home in Playa Blanca Rio Hato
4.79 out of 5 average rating, 28 reviewsComfortable apartment with pool and close to the beach
Nov 30 – Dec 7
Vacation home in Maria Chiquita
4.84 out of 5 average rating, 37 reviewsPlaya Escondida apt 200 mt2, 4r 4b waterfront
Jul 7 – 14
Destinations to explore
- Rentals with a fire pit Panama
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- Townhouse rentals Panama
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- Beach condo rentals Panama
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- Island rentals Panama
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- Serviced apartment rentals Panama
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- Cabin rentals Panama
- Treehouse rentals Panama
- Rentals with outdoor seating Panama
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- Bed and breakfasts Panama
- Nature eco lodge rentals Panama
- Wheelchair accessible rentals Panama
- Monthly Rentals Panama
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- Rentals with a sauna Panama
- Rentals with pools Panama
- Hostel rentals Panama
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- Cottage rentals Panama
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- Farmstay rentals Panama
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- Rentals with a hot tub Panama
- Rentals with a kayak Panama
- Rentals with an accessible height bed Panama
- Rentals with breakfast Panama
- Family-friendly rentals Panama
- Rentals with a fireplace Panama
- Chalet rentals Panama
- Rentals with a patio Panama
- Tiny house rentals Panama
- Rentals with an EV charger Panama
- Condo rentals Panama
- Fitness-friendly rentals Panama
- Rentals with beach access Panama
- Rentals with a washer and dryer Panama
- Rentals with lake access Panama
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