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House vacation rentals in Los Santos Province

Find and book unique houses on Airbnb

Top-rated house rentals in Los Santos Province

Guests agree: these houses are highly rated for location, cleanliness, and more.

Superhost
Home in Pedasí
Ocean View From The Jungle!
Welcome! 20% off for March Madness!! This home has been recently updated & returned to its original glory. There are 4 well appointed bedrooms, each has its own private bathroom. All bed linens are 100% egyptian cotton. The kitchen is very well stocked and you can be sure that you will be able to cook amazing meals for the whole family. Enjoy your meals outside, overlooking the pool and the jungle or inside... as there are 2 dining areas . The pool is nothing short of spectacular!
Jul 2 – 9
$283 per night
5.0 out of 5 average rating, 4 reviews
Guest favorite
Home in Pedasí
3 min to Pedasi, 5 min to the Beach, Private Pool!
Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi
Jan 19 – 26
$149 per night
4.93 out of 5 average rating, 102 reviews
Guest favorite
Home in Chitré
Country House Like in the City / La Casita
Villa Oregon les ofrece una casa, fresca rodeada de árboles y naturaleza. Cuenta con áreas amplias para descansar. Ubicación céntrica, cerca de Centros comerciales, restaurantes, estación de autobuses y acceso directo a una ciclovía en Chitré. Tenemos facilidades como entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, aire acondicionado, agua caliente y WiFi. Los huéspedes contarán con fruta de bienvenida! ENG, POR, FRE and ITA Spoken!
Aug 18 – 25
$50 per night
4.87 out of 5 average rating, 38 reviews

Popular amenities for Los Santos Province house rentals

House rentals with a pool

Superhost
Home in Santo Domingo
3 bedroom 2 bath with pool & bonus rooms!
Jun 21 – 28
$81 per night
4.8 out of 5 average rating, 5 reviews
Guest favorite
Home in Playa Venao
Next to Beach Club: Blue 2 Bedroom Family Villa
Sep 8 – 15
$252 per night
4.93 out of 5 average rating, 14 reviews
Superhost
Home in Playa Venao
Surf Venao! Walk to the Beach! 3b+2b Casa Palma 4
Jan 10 – 17
$299 per night
5.0 out of 5 average rating, 4 reviews
Superhost
Home in Cambutal
Casa Gerard
Jul 8 – 15
$157 per night
4.5 out of 5 average rating, 4 reviews
Guest favorite
Home in Búcaro
Casa Iguana 3 -Sleep 4-queen bed & 1 bunk bed
Sep 23 – 30
$103 per night
4.89 out of 5 average rating, 38 reviews
Superhost
Home in Chitré
NINA HOUSE, spacious and cool house in Chitré.
Jun 29 – Jul 6
$99 per night
4.77 out of 5 average rating, 44 reviews
Superhost
Home in Pedasi
Casa Del Amor in Pedasi Panama
Jun 21 – 28
$553 per night
New place to stay
Guest favorite
Home in Pedasi
2/2 Private Oasis Pedasi's best location & rental!
Oct 13 – 20
$92 per night
5.0 out of 5 average rating, 11 reviews
Guest favorite
Home in Pedasí
Beautiful Home, Birds, Monkeys, Pool, Trail
Mar 10 – 17
$100 per night
5.0 out of 5 average rating, 23 reviews
Home in Playa Venao
Tropical house with private pool and ocean views
May 6 – 13
$286 per night
5.0 out of 5 average rating, 3 reviews
Home in Pedasí
Pedasí :Andromeda Boroda 4-6 p. Beach, swimm. pool
Dec 16 – 23
$123 per night
4.89 out of 5 average rating, 38 reviews
Home in Pedasi
Super Private Beachfront 3BR Villa + Infinity Pool
Jun 25 – Jul 2
$302 per night
4.62 out of 5 average rating, 66 reviews

Weekly house rentals

Superhost
Home in La Villa de los Santos
House in La Villa de Los Santos
Jul 22 – 29
$41 per night
4.67 out of 5 average rating, 3 reviews
Superhost
Home in Las Tablas
Entire House "Las Marias"
Aug 6 – 13
$48 per night
4.5 out of 5 average rating, 24 reviews
Home in Tonosí
Beachfront Home w/key to empty beach
Feb 26 – Mar 5
$91 per night
4.93 out of 5 average rating, 15 reviews
Home in Playa Venao
Cocoloche / Oceanfront Family Compound
Jan 5 – 12
$500 per night
5.0 out of 5 average rating, 5 reviews
Guest favorite
Home in Cañas
La Hacienda Ojo de Agua * Full Summer Here *
Jan 4 – 11
$216 per night
4.94 out of 5 average rating, 16 reviews
Home in Pedasi
Casa Luna 2 bdrm 2 bath walk to square!
Aug 22 – 29
$72 per night
4.96 out of 5 average rating, 24 reviews
Guest favorite
Home in Bull Beach
Yellowfin Casa 3
May 7 – 14
$70 per night
5.0 out of 5 average rating, 11 reviews
Guest favorite
Home in San Juan Bautista
New house in Chitre located in a very central location
Jun 27 – Jul 4
$97 per night
5.0 out of 5 average rating, 10 reviews
Home in Chitré
Minimalist House In Chitre
Aug 31 – Sep 7
$71 per night
4.88 out of 5 average rating, 8 reviews
Home in Chitré
Grandpa's Casita Two Blocks From Downtown Chitré
Jul 22 – 29
$32 per night
4.62 out of 5 average rating, 13 reviews
Home in Las Escobas del Venado
Exclusive villa with infinity pool and direct acce
Jan 7 – 14
$490 per night
4.73 out of 5 average rating, 11 reviews
Home in Cambutal
Windward View of the Pacific
Oct 3 – 10
$132 per night
4.59 out of 5 average rating, 27 reviews

Private house rentals

Guest favorite
Home in Las Tablas
La casita de Cuca
Apr 18 – 25
$315 per night
4.8 out of 5 average rating, 5 reviews
Home in Las Tablas
Las Casa De Abuelita
Mar 22 – 29
$56 per night
4.8 out of 5 average rating, 5 reviews
Home in Los Santos
Family home
Oct 2 – 9
$103 per night
5.0 out of 5 average rating, 3 reviews
Home in Chitre
Cozy and centrally located house
May 23 – 28
$55 per night
4.64 out of 5 average rating, 22 reviews
Home in Pedasi
KASITA MAMAINA - Beautiful house in Pedasi
Mar 19 – 26
$69 per night
4.63 out of 5 average rating, 32 reviews
Home in Chitré
Spacious and comfortable residence
Oct 8 – 15
$92 per night
4.67 out of 5 average rating, 3 reviews
Home in Las Tablas
I will heal Las Tablas 3 Rooms 8 people
Mar 4 – 11
$177 per night
5.0 out of 5 average rating, 3 reviews
Home in Chitré
Cozy country house.
Jan 4 – 11
$38 per night
4.57 out of 5 average rating, 7 reviews
Home in Chitré
Brisas de los guayacanes casa 253
Jun 10 – 17
$100 per night
4.5 out of 5 average rating, 14 reviews
Home in Pedasi
PEDASI HOUSE
Jun 16 – 23
$75 per night
4.57 out of 5 average rating, 7 reviews
Home in Las Escobas del Venado
Villa #12 at Blue Playa Venao
May 24 – 31
$320 per night
New place to stay
Home in Playa Venao
Casa Ina - Panoramic Views w/pool
Jun 28 – Jul 5
$314 per night
New place to stay

Destinations to explore