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Villa vacation rentals in Los Santos Province

Find and book unique villas on Airbnb

Top-rated villa rentals in Los Santos Province

Guests agree: these villas are highly rated for location, cleanliness, and more.

Guest favorite
Villa in Playa Venao
Villa Verde - Luxury&Cozy Villa 1BR #26 BlueVenao
Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows
Feb 12 – 19
$196 per night
5.0 out of 5 average rating, 18 reviews
Guest favorite
Villa in Cañas
Residence Denter Tumas
We long for magnificence, seeking it out in all we do and wherever we travel. Can you imagine a better scenario for a uniquely curated residence than between green hills where both legend and myth come alive? Here you will feel like time has stopped and been replaced by a mysterious silence you can only recognize as pure energy. Come create extraordinary memories that will be forever woven into the fabric of what we call life, where luxury and style meet paradise in a truly unique estate.
Apr 20 – 27
$500 per night
5.0 out of 5 average rating, 15 reviews
Guest favorite
Villa in PA
Playa Venao, Blue Venao Beach Resort Villa 30
Playa Venao, P.H. Blue Venao Beach Resort Villa 30 is located on an upscale, luxury private resort located at one of Panama's best surfing beaches. We are located about four hours away from Panama City, 25 minutes from the town of Pedasi. The refreshing waters of the Pacific Ocean and the Nature of the area makes Venao a top vacation destination that offers activities such as, Surfing, Fishing, Horse Riding, Whale, Birds, Monkey, and Turtle Watching, Hiking. A 2 bedrooms, 2 bath Villa.
Mar 25 – Apr 1
$399 per night
5.0 out of 5 average rating, 26 reviews

Popular amenities for Los Santos Province villa rentals

Private villa rentals

Villa in Pedasi
Elegant Villa Cascada in Pedasi, 5 bdrm sleeps 11
Jul 10 – 17
$270 per night
4.53 out of 5 average rating, 40 reviews
Villa in Cambutal
Pacific Escape
Jun 28 – Jul 5
$114 per night
4.52 out of 5 average rating, 23 reviews
Villa in Pedasi
2 bdrm Villa, walk to square
Oct 27 – Nov 3
$87 per night
New place to stay
Villa in Las Escobas del Venado
Gorgeous + Eclectic | 3BR Villa 11@BlueVenao
Aug 9 – 16
$369 per night
4.73 out of 5 average rating, 11 reviews
Villa in Playa Venao
Cozy & Comfy | 2BR Villa 7@BlueVenao
Nov 20 – 27
$214 per night
4.71 out of 5 average rating, 7 reviews
Villa in Playa Venao
Just Steps from the Beach | 3BR Villa 36@BlueVenao
Jul 7 – 14
$369 per night
4.46 out of 5 average rating, 13 reviews
Villa in Las Escobas del Venado
Modern & Cozy | 2BR Villa 12@BlueVenao
Nov 20 – 27
$214 per night
New place to stay
Villa in Las Escobas del Venado
Cozy & Coastal | 3BR Villa 23@BlueVenao
Aug 5 – 12
$369 per night
4.25 out of 5 average rating, 4 reviews
Villa in Las Escobas del Venado
Stylish + Cozy | 3BR Villa 29 @BlueVenao
Apr 12 – 19
$401 per night
4.0 out of 5 average rating, 3 reviews
Villa in Pedasi
Village House #4 - 10 min walk to Pedasí town!
Feb 21 – 28
$98 per night
4.38 out of 5 average rating, 21 reviews
Villa in Las Escobas del Venado
Beautiful + Boho | 2BR Villa 14@BlueVenao
Jun 14 – 21
$257 per night
New place to stay
Villa in Pedasi
2 bdrm home, Enjoy nature, Walk to town center
Jul 24 – 31
$80 per night
New place to stay

Luxury villa rentals

Villa in Playa Venao
Villa Nomada - Barefoot Luxury 👑 Beach Front Villa
Nov 18 – 25
$671 per night
4.79 out of 5 average rating, 39 reviews
Villa in Los Santos Province
Luxury Ocean View Villa Esplendorosa
May 14 – 21
$994 per night
4.86 out of 5 average rating, 21 reviews
Guest favorite
Villa in Playa Venao
Casa Aqua: Amazing beach front house - Playa Venao
Jul 27 – Aug 3
$540 per night
4.98 out of 5 average rating, 57 reviews
Villa in Playa Venao
Ocean view luxury Villa, Private Pool 4BD 8PPL
Apr 8 – 15
$765 per night
4.5 out of 5 average rating, 6 reviews
Villa in Las Escobas del Venado
Beachfront Luxury + Pool | 4BR Villa 50@BlueVenao
Jul 25 – Aug 1
$757 per night
New place to stay
Villa in Las Escobas del Venado
Villa Ceviche, Home at the Heart of Venao
May 10 – 17
$528 per night
New place to stay
Villa in Pedasi
"The White Villa"
Nov 13 – 20
$756 per night
4.38 out of 5 average rating, 8 reviews
Villa in Las Escobas del Venado
Blue Villa, Lux Home at Venao
Apr 9 – 16
$643 per night
New place to stay

Villa rentals with a pool

Superhost
Villa in Pedasí
Drones Pedasi Ranch- Beach_Pool_Folks Fest_Fishing
May 1 – 8
$158 per night
4.8 out of 5 average rating, 10 reviews
Villa in Playa Venao
Best Located Villa in Blue with Private Pool
May 19 – 26
$297 per night
4.8 out of 5 average rating, 10 reviews
Villa in PA
Casa Colibrí, Pedasí
Oct 21 – 28
$243 per night
4.8 out of 5 average rating, 10 reviews
Villa in Las Escobas del Venado
Villa Tortugas Playa Venao
Nov 27 – Dec 4
$315 per night
5.0 out of 5 average rating, 5 reviews
Villa in Las Escobas del Venado
VENAO - BLUE27 COZY VILLA
Sep 9 – 16
$210 per night
4.86 out of 5 average rating, 14 reviews
Villa in Cambutal
Incredible Tao House at oceanfront Zen Sanctuary
Aug 24 – 31
$234 per night
New place to stay
Villa in Playa Venao
Villa Bella Vista
May 10 – 17
$460 per night
New place to stay
Superhost
Villa in Playa Venao
Villa Ocean Pearl Venao
Jun 20 – 27
$180 per night
4.59 out of 5 average rating, 82 reviews
Superhost
Villa in Pedasí
Villa Paraíso Pacifico
Aug 7 – 14
$419 per night
4.62 out of 5 average rating, 13 reviews
Guest favorite
Villa in Las Escobas del Venado
Family Perfect Getaway | 3BR Villa 6 @BlueVenao
May 6 – 13
$369 per night
5.0 out of 5 average rating, 6 reviews
Villa in Playa Venao
2min walk-to-the-Beach | 3BR Villa 31@BlueVenao
Dec 11 – 18
$294 per night
4.63 out of 5 average rating, 8 reviews
Villa in Playa Venao
Lovely Bohemian Style | 3BR Villa 35 @BlueVenao
Mar 3 – 10
$348 per night
4.73 out of 5 average rating, 11 reviews

Destinations to explore