Villa vacation rentals in Isle of Palms

Find and book unique villas on Airbnb

Top-rated villa rentals in Isle of Palms

Guests agree: these villas are highly rated for location, cleanliness, and more.

Guest favorite
Villa in kiawah island
Kiawah Villa 2 Bed/2 Bath
Kiawah Island - 2 Bedroom / 2 full baths inTennis club villa. Extra sleeping with sofa bed. Dog (2) friendly. 10 minute walk to beach. Close to Sanctuary hotel and Roy Barth tennis. High speed internet and desk. Fully furnished -all that you need. high end linens, upgraded beds, beach chairs and fully stocked kitchen. Enjoy coffee on screened in porch. Access to resort golf or tennis and restaurants. Book activities reservations early. Sorry-there is no pool access.
Aug 12 – 19
$284 per night
4.94 out of 5 average rating, 141 reviews
Guest favorite
Villa in Johns Island
Renovated Kiawah Villa Steps to Beach
Welcome to Mimosa Manor, a completely renovated 1 bedroom/ 1 Bath villa just steps to beautiful East Beach on Kiawah Island. Villa sleeps four comfortably with king master suite AND queen size Murphy bed. Mimosa Manor is a first floor villa in the Mariner's Watch Complex (within the gates on Kiawah Island) with a gorgeous wooded view and is just a 35-minute drive from the cobblestone clad streets of downtown Charleston. Business License Number: RBL20-000419
May 1 – 8
$265 per night
4.94 out of 5 average rating, 201 reviews
Guest favorite
Villa in Johns Island
Updated beach getaway with amazing lagoon views
Newly renovated. Clean and fresh beach decor. 950 sq ft "treehouse" on beautiful Seabrook Island with lots of extras. Huge floor to ceiling doors and windows that overlook a beautiful lagoon with wildlife galore. Gaze outside for hours and view amazing birds, deer, fish, turtles, and even an alligator or two! Large deck with seating for six and a grill. WiFi and three smart tvs. Seabrook Island Business License # 20191576 MAXIMUM 2 VEHICLES
Sep 1 – 8
$236 per night
4.97 out of 5 average rating, 141 reviews

Popular amenities for Isle of Palms villa rentals

Villa rentals with a pool

Guest favorite
Villa in Seabrook Island
Private island villa with luxury resort amenities!
Mar 11 – 18
$159 per night
4.82 out of 5 average rating, 56 reviews
Guest favorite
Villa in Seabrook Island
Beautifully Transformed Upper Level Deluxe Villa
Oct 7 – 14
$163 per night
4.92 out of 5 average rating, 77 reviews
Guest favorite
Villa in Seabrook Island
Great Rates! Screen Porch! Pool!
Apr 5 – 12
$121 per night
4.92 out of 5 average rating, 83 reviews
Guest favorite
Villa in Seabrook Island
Upscale Villa, Amenity Included! Dog Friendly
Jul 2 – 9
$328 per night
4.89 out of 5 average rating, 28 reviews
Superhost
Villa in Seabrook Island
Golf view Seabrook Beach Villa w/Pool & Pickleball
Aug 13 – 20
$372 per night
4.85 out of 5 average rating, 26 reviews
Guest favorite
Villa in Charleston
Villa overlooking Charleston close to Folly Beach
Jul 1 – 8
$340 per night
5.0 out of 5 average rating, 94 reviews
Guest favorite
Villa in Seabrook Island
Newly Remodeled Villa, 5 Minute Walk to Beach
Nov 5 – 12
$401 per night
4.92 out of 5 average rating, 49 reviews
Superhost
Villa in Folly Beach
83 Waters Edge - Comfy Cool - Pool
May 8 – 15
$381 per night
4.84 out of 5 average rating, 61 reviews
Guest favorite
Villa in Seabrook Island
Beautiful and Spacious 2 Bedroom Courtside Villa!
Jan 18 – 25
$200 per night
4.97 out of 5 average rating, 58 reviews
Villa in Isle of Palms
Beachfront IOP Villa with Outdoor Pool. Remodeled!
Feb 9 – 16
$385 per night
4.73 out of 5 average rating, 22 reviews
Villa in Isle of Palms
Updated 2BR | Balcony | Pool | Dock
Dec 10 – 17
$137 per night
4.76 out of 5 average rating, 45 reviews
Villa in Isle Of Palms
7C Seagrove - Sweetgrass
Oct 20 – 27
$314 per night
4.78 out of 5 average rating, 32 reviews

Private villa rentals

Guest favorite
Villa in Kiawah Island
4401 Windswept Villa, Kiawah Island, SC
Sep 24 – Oct 1
$257 per night
4.98 out of 5 average rating, 105 reviews
Guest favorite
Villa in Kiawah Island
Lagoon view villa with office, easy walk to beach!
Oct 13 – 20
$230 per night
4.96 out of 5 average rating, 82 reviews
Guest favorite
Villa in Seabrook Island
711 Spinnaker centrally located to EVERYTHING!
Dec 16 – 23
$300 per night
4.86 out of 5 average rating, 51 reviews
Guest favorite
Villa in Kiawah Island
Clean & Comfortable! Steps to the beach!
Mar 10 – 17
$185 per night
4.93 out of 5 average rating, 95 reviews
Guest favorite
Villa in Edisto Island
Relax in a Happy Place
Aug 11 – 18
$202 per night
4.97 out of 5 average rating, 36 reviews
Guest favorite
Villa in Kiawah Island
Picturesque View in Parkside!
Oct 16 – 23
$241 per night
4.8 out of 5 average rating, 25 reviews
Guest favorite
Villa in Edisto Island
Loft-e-Lagoon *No Cleaning Fee*
Sep 13 – 20
$162 per night
4.76 out of 5 average rating, 46 reviews
Superhost
Villa in Seabrook Island
Vaughan Villa | Golf Course Views & Near Beach
Sep 26 – Oct 3
$215 per night
4.75 out of 5 average rating, 4 reviews
Guest favorite
Villa in Edisto Island
Waves of Change
Aug 17 – 24
$203 per night
4.95 out of 5 average rating, 22 reviews
Villa in Kiawah Island
Spacious & Steps to the Beach at Kiawah Island
Nov 17 – 24
$239 per night
4.68 out of 5 average rating, 22 reviews
Guest favorite
Villa in Mount Pleasant
Coastal 3BR | Patio | Dog Friendly
Sep 9 – 16
$394 per night
4.92 out of 5 average rating, 12 reviews
Guest favorite
Villa in Kiawah Island
Expansive Lagoon Views for 3 bed/3 bath villa
Dec 13 – 20
$414 per night
5.0 out of 5 average rating, 7 reviews

Luxury villa rentals

Guest favorite
Villa in Isle of Palms
Beach Club Villa 30 - Oceanfront! Pool! Walkout!
Sep 13 – 20
$631 per night
5.0 out of 5 average rating, 14 reviews
Guest favorite
Villa in Kiawah Island
Spacious new 2BR Villa across beach near Sanctuary
Jun 25 – Jul 2
$569 per night
4.96 out of 5 average rating, 94 reviews
Superhost
Villa in Kiawah Island
Incredible, completely renovated oceanfront villa
Sep 18 – 25
$780 per night
5.0 out of 5 average rating, 3 reviews
Guest favorite
Villa in Kiawah Island
Ocean Front! Beach is steps away. Clean and Crisp!
Nov 23 – 30
$679 per night
5.0 out of 5 average rating, 26 reviews
Superhost
Villa in Isle of Palms
Surfside Villa | Oceanfront Luxury | 8 Beach Club
Mar 6 – 13
$757 per night
New place to stay
Superhost
Villa in Seabrook Island
Seaside Therapy - An iTrip Vacations Home
Jul 15 – 22
$854 per night
New place to stay
Guest favorite
Villa in Kiawah Island
Luxury Penthouse 2 BR 3 Bath Villa with Ocean View
Nov 18 – 25
$631 per night
5.0 out of 5 average rating, 18 reviews
Guest favorite
Villa in Seabrook Island
Luxury Seabrook Isl Beach Condo
Sep 14 – 21
$533 per night
5.0 out of 5 average rating, 7 reviews
Villa in Isle of Palms
Oceanfront Villa in Wild Dunes! Community Pool!
Oct 3 – 10
$617 per night
5.0 out of 5 average rating, 4 reviews
Guest favorite
Villa in Kiawah Island
Open floor plan 2 Bedroom Turtle Cove Villa
Nov 26 – Dec 3
$504 per night
4.94 out of 5 average rating, 52 reviews
Villa in Johns Island
Captivating Sunsets! 2BR/2.5BA Villa! Pet Friendly! Amenity Cards Available!
Jun 18 – 25
$529 per night
5.0 out of 5 average rating, 3 reviews
Guest favorite
Villa in Isle of Palms
Summer House 109 - Beach Walkout - 30 Secs to Sand
Jul 9 – 16
$658 per night
4.88 out of 5 average rating, 16 reviews

Quick stats about villa rentals in Isle of Palms

Total rentals

90 properties

Rentals with dedicated workspaces

60 properties have a dedicated workspace

Rentals with a pool

80 properties have a pool

Family-friendly rentals

70 properties are a good fit for families

Total number of reviews

1.2K reviews

Nightly prices starting at

$110 before taxes and fees

Destinations to explore