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Lake house vacation rentals in Seneca
Find and book unique lake houses on Airbnb
Top-rated lake house rentals in Seneca
Guests agree: these lake houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Seneca lake house rentals
Waterfront lakehouse rentals
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Home in Anderson
4.87 out of 5 average rating, 173 reviewsLake Living with Amazing Views of Lake Hartwell
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Home in Townville
4.99 out of 5 average rating, 102 reviewsSweet Serenity - Rest Relax Enjoy
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Home in Anderson
4.95 out of 5 average rating, 99 reviewsClemson 15 Miles, Lake Hartwell, Waterfront
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Home in Fair Play
5 out of 5 average rating, 7 reviewsWaterfall Cove - Prime
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Home in Seneca
4.92 out of 5 average rating, 76 reviewsCharming Secluded Lake House Convenient to Clemson
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Home in Seneca
4.81 out of 5 average rating, 16 reviewsLake Hartwell Beauty with Dock. Minutes to Clemson
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Home in Seneca
4.95 out of 5 average rating, 56 reviewsGood Times @ Clemson / Lake Hartwell
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Home in Seneca
5 out of 5 average rating, 3 reviewsSweet Tea Retreats Lake Keowee
Pet-friendly lake house rentals
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Home in Hartwell
4.93 out of 5 average rating, 107 reviewsLake house waterfront, 10 min to downtown w Kayaks
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Home in Easley
4.91 out of 5 average rating, 134 reviewsLarge lake house - 15 min to Downtown Greenville
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Home in Seneca
4.93 out of 5 average rating, 98 reviewsGetaway on Lake Hartwell: Pontoon Rental, Clemson
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Home in Seneca
4.93 out of 5 average rating, 88 reviewsThe Marina House, at the edge of Lake Keowee.
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Home in Toccoa
4.93 out of 5 average rating, 60 reviewsA Travelers Nest ~ Lake House
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Home in Seneca
4.96 out of 5 average rating, 24 reviewsNew! Peaceful Lakefront Home on Keowee!
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Home in Townville
5 out of 5 average rating, 21 reviewsFish, boat, swim and relax on Lake Hartwell
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Home in Seneca
5 out of 5 average rating, 12 reviewsKeowee Lakeside with pool for 16
Private lake house rentals
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Home in Townville
5 out of 5 average rating, 26 reviewsEntire Lake house on deep water cove.
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Home in Tamassee
5 out of 5 average rating, 29 reviewsWhitewater Lake Front Cottage
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Home in Seneca
5 out of 5 average rating, 37 reviewsQuiet Lake Home 5 Min to Clemson
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Home in Anderson
4.98 out of 5 average rating, 41 reviewsThe Shanty on Waites
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Home in Seneca
4.87 out of 5 average rating, 23 reviewsBeautiful Lakefront Home on Lake Keowee w/ dock
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Home in Seneca
5 out of 5 average rating, 57 reviewsClemson Lake Hartwell Retreat! Dock & Kayaks, 4BR
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Home in Salem
4.86 out of 5 average rating, 14 reviewsKeowee Key - Lake, deck, golf & tennis!
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Home in Six Mile
5 out of 5 average rating, 10 reviewsSunset Point on Lake Keowee
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