Guesthouse vacation rentals in Alachua County

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Top-rated guesthouse rentals in Alachua County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Alachua

4.83 out of 5 average rating, 325 reviews

Beautiful Modern Cottage Pastoral Country Setting

This modern 925 sq ft house is just 5 min to Alachua and 3 min to I-75. It's about 20 minutes from the springs and 20 mins from Gainesville FL. It has central air conditioning and a kitchenette which shares space with my water purification system. This means that when you bathe, shower or brush your teeth you will be doing it with highly purified water. Also means if you are in that area when it is running you will hear it . Room is soundproof and system can be put on standby with a button press

Guest favorite

Guesthouse in Newberry

5 out of 5 average rating, 15 reviews

Casita Tranquila

Experience the epitome of modern luxury at our exquisite Casita nestled in a highly sought after neighborhood. Just minutes from UF, Shands, VA Hospital and downtown Gainesville, as well as many of the most popular springs Fla has to offer. Step outside and find yourself amid a vibrant neighborhood. Whether you are a solo traveler, going to a sporting event or just a romantic getaway, our studio offers the ideal urban escape. Enjoy the comfort of a home away from home. We can’t wait to host you!

Guest favorite

Guesthouse in Gainesville

4.87 out of 5 average rating, 192 reviews

Sunflower Acres Cottage

Cute, cozy, freshly remodeled, private guest house on a beautiful 5 acre farm. Enjoy your own backyard herb garden with privacy fence, picnic table and fire pit. New kitchen with gas stove, microwave, toaster oven, coffee-maker, and dining area perfect for enjoying meals. The bedroom is equipped with a smart TV, queen bed, & extra blankets. This country getaway is near the University of Florida (12 miles), Blue Springs (21 miles) Ginnie Springs (24 miles), and historic High Springs (15 miles).

Guest favorite

Guesthouse in Gainesville

4.97 out of 5 average rating, 501 reviews

Private Studio-Walking Distance to the UF Stadium

Enjoy your Gainesville stay in this mid-century modern studio 1/2 a mile from UF and 2 miles from UF Health Shands! No detail was overlooked in this 250-square-foot beautifully designed detached guest house with an abundance of natural light, high-end finishes, and endless amenities - kitchenette, mini fridge/freezer, smart TV, Amazon Echo, and more! This conveniently located private and quiet space in the heart of Gainesville is perfect for anyone visiting for just one night or a few weeks.

Guest favorite

Guesthouse in Gainesville

4.98 out of 5 average rating, 183 reviews

Walk to UF! Historic King Bed Loft w/ Private Deck

If you are visiting Gainesville, look no further than Camellia Loft. This historic gem was built in 1924 and has been freshly renovated to bring it into the modern era. Enjoy the birdsong and majestic trees from your private deck overlooking the backyard—or relax inside as light streams through the loft's massive skylights. Only 0.5 miles to UF campus and exactly 1 mile to the stadium, you can easily walk to campus or games. Unwind by the shared fire pit or enjoy cooking on the grill

Guest favorite

Guesthouse in Gainesville

4.91 out of 5 average rating, 141 reviews

Private cottage convenient to downtown and UF.

Quiet, private studio cottage with screened in porch that look out to the spacious yard and gardens. Off street parking, walking distance to downtown, Santa Fe downtown campus, Dragon Rises, Five Elements, and 2.5+ miles to UF/Shands. Easy accèss to the airport, libraries, museums, local parks, swimming, and biking trails. Kayaking, cave diving, and other activities just a few miles away. Enjoy your stay with a comfortable queen size bed, internet, coffee, and a modest kitchen.

Guest favorite

Guesthouse in Gainesville

4.9 out of 5 average rating, 380 reviews

B&B's Downtown Steampunk

Grab a slice of Wow in this turn-of-the century Steampunk design carriage house in Gainesville’s picturesque Bed and Breakfast District. It’s a stone’s throw from downtown’s fine dining, coffeehouses, craft beer breweries, and the famous Bo Diddly Square’s music venue. Check out plays and movies the historic Hippodrome . . . all this is within a walking radius of a few short blocks. Enjoy your restful retreat’s unique style that combines historical elements with science fiction.

Guest favorite

Guesthouse in Archer

4.95 out of 5 average rating, 131 reviews

Your own private space of peace and quiet.

Keep it simple at this peaceful and centrally-located place. While being only 15 miles from the nightlife of downtown Gainesville, this is country living at it best. With no street lights the stars are bright and easily counted. The mornings are bright and full of the music of bird songs. The cute 2 bedroom apartment is on the SECOND FLOOR, it is easy to get lost in the whisper of the trees. This is a place to rest your soul and unwind.

Guest favorite

Guesthouse in Micanopy

4.92 out of 5 average rating, 147 reviews

Private bed and bath above detached garage.

Close to Paynes Prairie Preserve State Park, Micanopy's unique downtown and a short easy drive to UF campus. North of Micanopy on Highway 441 across from Lake Wauberg. A common private driveway from the highway leads up to our two story home and two story detached garage. Uber not a good option. Good for couples, solo adventurers, and business travelers; and great for Gator friends and fans. Smoke free and no pets please.

Guest favorite

Guesthouse in Gainesville

4.96 out of 5 average rating, 115 reviews

Little Willa- an open plan guesthouse with kitchen

Kick back and relax in this calm, stylish space. Pet friendly and located in the quiet Duckpond neighborhood just a mile walk from the center of downtown Gainesville. Tom Petty Park at the end of our street includes playground, vollleyball net, tennis courts, dog park etc. Gainesville Bike Trail entrance just 1/2 mile from house. Private entrance to guesthouse with shared brick courtyard and parking.

Guest favorite

Guesthouse in Alachua

4.94 out of 5 average rating, 17 reviews

Sweetwater Studio, on 5 beautiful acres

Gorgeous Upstairs Studio Apartment, nestled on a stunning 5 acre property. Relax & unwind in this Oasis of green. * 15 minutes to stunning, freshwater springs & rivers. * 4 min to shops, restaurants, cafes. * 7 min to High Springs. * 10 min to downtown Alachua. * 20 min to Gainesville. Perfect for a romantic getaway, solo retreat, or family vacation. Contemporary furnishings built in Jan 2024.

Guest favorite

Guesthouse in Gainesville

4.94 out of 5 average rating, 121 reviews

Getaway Guesthouse

Cute, detached, studio-style guest house with private entrance. It is quiet and peaceful, but only minutes from the University of Florida, parks, and restaurants. Kitchen w/refrigerator, microwave, toaster oven, coffee-maker, and dining area perfect for enjoying breakfast before exploring. Comfortable Queen-sized bed for a goodnight's sleep.