Guesthouse vacation rentals in Jacksonville

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Top-rated guesthouse rentals in Jacksonville

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Guest favorite

Guesthouse in Southeast Jacksonville

4.9 out of 5 average rating, 204 reviews

Studio Suite in Beautiful Central Neighborhood

Studio guest suite with queen bed and kitchenette in beautiful Miramar neighborhood, just 5 minutes from historic San Marco. Close to restaurants, grocery, MD Anderson Cancer Center and Wolfson Children's Hospital. Owners live in main house on site but suite has its own private entrance and parking. You will have access to an outdoor dining space and fenced in backyard. Dogs live on premises but will not interfere, although you may hear barking. Sofa bed available if needed, please inquire.

Guest favorite

Guesthouse in Beaches

4.97 out of 5 average rating, 301 reviews

Private Studio Apartment 1 Mile from Ocean

Spotless - bright and airy private studio apartment - located 1 mile from ocean. Detached apartment is located behind the main house, you have a private entry to come and go as you please. Perfect for someone vacationing, visiting Mayo Clinic, TPC or short term work assignment in Jacksonville or the surrounding area. 5 minute bike ride to beach, restaurants and shopping - and we provide the bikes! Unit has separate Central Air Condition and Heating Unit and Controls, you are in charge!

Guest favorite

Guesthouse in Avondale

4.99 out of 5 average rating, 209 reviews

Luxury Avondale Guest House, Walk to Shops

Featured in the Jacksonville Home Magazine! The Luxury Avondale Guest House is in the exquisite historic neighborhood of Avondale. Ten minutes from downtown sports & entertainment complexes, and several major health care facilities, St. Vincent's Hospital, Baptist Medical Center and the world renowned MD Anderson Cancer Center. Three short blocks to “The Shoppes of Avondale,” with an outstanding array of restaurants and venues to enjoy a streetside café-style meal, cocktail and desserts.

Guest favorite

Guesthouse in Riverside

4.95 out of 5 average rating, 126 reviews

Modern Riverside Private Studio

Enjoy a stylish experience at this brand new renovated suite in the heart of Riverside. You will find everything you need in our cozy and private studio. The space includes small kitchen with mini fridge, microwave, toaster, and coffee maker. Within walking distance to many restaurants, breweries, coffee shops and the best bike rental shop in town. We are centrally located to walk to Historic Five Points, King Street, or the St John’s waterfront and a short drive to San Marco & Downtown.

Guest favorite

Guesthouse in Murray Hill

4.94 out of 5 average rating, 187 reviews

Large 1 bedroom Cottage with full kitchen

This is a full size one bedroom house with full brand new kitchen and private entrance. The entire place was renovated late 2021. A luxurious king size bed awaits you and a twin sized sofa bed for one adult or two kids. The kitchen has a full sized brand new oven, stove, microwave, dishwasher and fridge and is stocked with utensils etc so you can easily make full meals or stay for an extended time. There's one free off-street parking spot available and plentiful free street parking.

Guest favorite

Guesthouse in Southeast Jacksonville

4.9 out of 5 average rating, 249 reviews

Private Bungalow with Pool/55 tv

"The Oasis" is an cozy backyard guest room, detached and separate from the main house, in a beautiful outdoor oasis located in an older neighborhood in the center of Jacksonville, close to I-95, with easy access to everything. 5-7 minutes (4-5 miles) from downtown, Convention Center, Veterans Memorial Arena, TIAA Bank Field (Jaguar Stadium) and Times Union Center, 20 min to Mayo Clinic (15 miles), 20 min to the beaches (18 miles). NOTE: No animals/pets or children under 12 allowed.

Guest favorite

Guesthouse in Southeast Jacksonville

4.96 out of 5 average rating, 160 reviews

Il Rifugio waterfront retreat on the ICW by Mayo!

This peaceful, quiet location on the intercoastal waterway is a perfect place to get away or stay close to Mayo clinic and relax among the bald eagles, owls, dolphins, manatees, etc. Completely private building with raised patio area for you to enjoy. Sleeps up to 4 (1 king size + 1 full size beds) . Close to beaches (4 miles), restaurants, Mayo clinic, 2.5 miles; TPC/ Sawgrass Golf ,10 miles; Saint JohnsTown Center shopping 10 miles; Jacksonville International Airport, 25 min.

Guest favorite

Guesthouse in Beaches

4.99 out of 5 average rating, 146 reviews

Tropical guest house a few blocks from the beach

Take it easy at this unique and tranquil getaway. Private modern quest house located on lush tropical grounds behind main house. Includes: loft bedroom, full bath, kitchenette, wifi, air conditioning, private patio, and outdoor shower. Property is gated with parking. Walking distance to beach, bars, shops and restaurants. Hammock, volley ball, firepit, BBQ and bikes available upon request. Pets welcome. Fishing pier, boating, kayaking and golf options within a short distance.

Guest favorite

Guesthouse in Avondale

4.97 out of 5 average rating, 119 reviews

Stylish Bungalow Near Dining,Parks & Entertainment

Welcome to our charming bungalow in Jacksonville's historic Avondale neighborhood. Perfect for couples or small families, enjoy a cozy queen bed, high-speed Wi-Fi, and a 50-inch HDTV with Roku. The fully-equipped kitchen boasts retro appliances and a delightful dining area. Step outside to our pet-friendly garden with a spacious deck for relaxation. With award-winning restaurants and beautiful parks just a stroll away, this is your ideal retreat for both adventure and relaxation.

Guest favorite

Guesthouse in Avondale

4.95 out of 5 average rating, 604 reviews

The Captain's Quarters o|--)

This two story loft garage is detached and is set in the back of the property 45 feet from the main house. The first floor has the kitchen and living space, then walk up the spiral staircase to the bedroom with cathedral ceiling with track lights and ensuite bathroom. I love dogs and allow them with permission first. No pets without prior approval (pet fee is min $50 per stay or $10 per day which ever is greater) My location is a short walk to Starbucks and other restaurants.

Guest favorite

Guesthouse in Avondale

4.98 out of 5 average rating, 196 reviews

Avondale Studio

Located in Avondale, Jacksonvilles historic district, this Garage Studio offers everything one needs for a getaway or a business trip. Walking distance to the Shoppes of Avondale. There are multiple restaurants/bars/outdoor cafe dining all within walking distance in either direction. The 2nd story garage apartment offers a balcony with views into Boone Park. Fully renovated in 2021 offering a full kitchen and bathroom. You have a private parking space as well.

Guest favorite

Guesthouse in Murray Hill

4.93 out of 5 average rating, 215 reviews

The Moody Loft (Murray Hill)

Kick back and relax in this calm, stylish space. Dimmable lights for your preference. It's within minutes of Jacksonville's best night life. Walk to Murray Hill's bars and restaurants. Less than 5 minute drive to Riverside's Historic 5 Points. Less than 10 minutes from downtown and 25 minutes from beaches. There's a small fence separating my main house, enjoy sitting outside. My Newfies might peek over the fence every now and then to say hello :)