Guesthouse vacation rentals in San Diego County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Escondido

4.92 out of 5 average rating, 639 reviews

Hilltop cabin retreat with lake & mountain views

Rustic hilltop cabin overlooking Lake Hodges. Surrounded by open canyons & mountains, you will feel like you're a million miles away from everything as you take in the views from the cabin, deck or the outside shower, swim in the saltwater pool, or relax by the fire bowl. A short walk to lake with boating, fishing & miles of hiking/mountain biking trails. Property offers swimming pool, fire bowl, and shaded arbor. SD Zoo Safari Park, wineries, breweries, & ocean beaches all within easy reach.

Jan 31 – Feb 7

$146 per night

Guest favorite

Guesthouse in Encinitas

4.99 out of 5 average rating, 149 reviews

Coastal Farm Sanctuary Stay. 20 min to the Beach.

Coastal Farm Sanctuary guest house, superbly finished. 20 min to beach. Quiet relaxing farm sanctuary retreat. Close to the beach, shops and restaurants. Our location offers an air of tranquility and peace, allowing you to unplug and unwind. There is a full kitchen, space for lounging, an elegant bathroom and a comfortable king sized bed with lush linens. The apartment has a modern country vibe, situated on 2.5 acre estate with privacy and breath-taking views. Please no pets and no smoking.

Jan 4 – 11

$153 per night

Guest favorite

Guesthouse in Encinitas

4.98 out of 5 average rating, 125 reviews

The Tiki Lounge, Leucadia, California

The Lounge is a quaint, cozy 400 sq. ft. one-bedroom detached guesthouse with lots of character in the "funky" community of Leucadia. Located just east of historic Highway 101 in a quiet neighborhood a mile from beach access, you're close to many eclectic shops, restaurants and entertainment. You'll also have access to a semi-private patio and shared access to our back yard, where, as of June 2023, Debe works 3 to 4 days a week in her studio. We really love it here and think you will too.

Jul 13 – 20

$117 per night

Guest favorite

Guesthouse in San Diego

4.93 out of 5 average rating, 356 reviews

Cozy Ocean Beach Casita

This cozy, clean casita is just 4 blocks to the beach, pier, great surfing, restaurants, bars, shopping, and Sunset Cliffs. You’ll love it for its walkability to everything you need. The casita is only 120 square feet, a very small space (small studio with everything in one room including the bathroom), for single occupancy only, but with everything you need to enjoy a San Diego getaway. It is great for solo travelers who want to be near the heart of Ocean Beach, San Diego, California.

Oct 17 – 24

$94 per night

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 283 reviews

Betty- Guesthouse near CBX & San Ysidro border

This comfy studio located in San Diego is the perfect spot for a quiet & cozy weekend retreat. Inside is bright & inviting with stylish spacious studio, private entrance from side gate, private patio with bbq & hanging hammocks; driveway parking spot & plenty of street parking! The view from the patio is very relaxing, making it the perfect weekend get away. Centrally located in a quiet & peaceful area within 5 minutes away from Plaza Las Americas & 10 minutes away from the CBX.

Feb 21 – 28

$109 per night

Guest favorite

Guesthouse in Encinitas

4.86 out of 5 average rating, 228 reviews

Sunset/Ocean View Guest House! Minutes to Beach

Sunset/Ocean view guest house (one bedroom with a sofa bed)--386 Sunset Drive, 92024. Quiet residential neighborhood, close to downtown Encinitas, and half a mile from Moonlight Beach. Balcony features a propane barbecue, table, chairs, chaise lounge, and a distant view of the sunset and ocean. Living room/dining/kitchen area includes sofa bed. Living room features a 45" flat screen and DVD player. Bedroom includes a natural gas fireplace, television, and DVD player.

Dec 26 – Jan 2

$126 per night

Guest favorite

Guesthouse in San Diego

4.98 out of 5 average rating, 185 reviews

North Park Garden Retreat Casita

Nestled between the urban neighborhoods of North and South Park, our sanctuary within the heart of the city is surrounded by a secret garden that gives the impression of a tropical oasis. The private casita is tucked in the backyard of the Host’s home and has french doors which open to the lush greenery of the garden. Whether vacationing, traveling for work, or looking for an ideal space for relaxation and renewal, this is the perfect place to enjoy your San Diego stay.

Aug 31 – Sep 7

$96 per night

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 145 reviews

Modern 1-Bdrm with A/C, 15 min to beach

Bright and inviting one bedroom with a open floorplan combined kitchen and living room, with toaster oven, hot plate, microwave, Keurig, fridge, rice maker, and all the amenities of a boutique junior suite, including 1000 ct. sheets, hypoallergenic feather bed, snacks, bottled water, any toiletry you might need and plenty of beach towels. Stay for 3 days or for the guest that may need a longer stay it is perfect for transitioning to the San Diego area.

Jul 10 – 17

$125 per night

Guest favorite

Guesthouse in Dulzura

4.97 out of 5 average rating, 579 reviews

Vineyard & Winery Guest House

A hidden gem! Get away and stay at the historic pioneer era Clark Ranch established in 1885. Our guest house sits above our winery tasting room and has its own private entrance and driveway. It's clean, cozy, and self-contained . Make it a weekend 'getaway' stay and sample our fine wines , and Estate Olive Oil. There is a tower in the vineyard where you can enjoy a glass of wine and watch the sun set. Balcony overlooks Dulzura Creek.

May 19 – 26

$126 per night

Guest favorite

Guesthouse in San Diego

4.96 out of 5 average rating, 125 reviews

Brand New Modern North Park View Apartment

This brand new North Park apartment is the perfect place to enjoy San Diego. The home is located on a quiet street in close proximity to Balboa Park, the San Diego Zoo, Downtown, Sea World, Old Town, Coronado Island, Seaport Village, and the airport. It is in walking distance to a number of renown restaurants, coffee shops, and breweries. Beautiful sunset views allow you to relax after a long day of taking in the city.

Jan 10 – 17

$106 per night

Guest favorite

Guesthouse in San Diego

4.9 out of 5 average rating, 944 reviews

Safe Hip Quiet GARDEN STUDIO / Northpark

Come to a quiet and stylish studio for social distancing. Check in contactless and enjoy! Cozy, hip and private garden studio with private entrance, private full bathroom and private deck. Studio house is in a large garden adjoining a craftsman-style house in the historic Northpark/ Morley Field District. Minutes away from coffee shops, breweries, Zoo, Balboa Park.

Dec 25 – Jan 1

$101 per night

Guest favorite

Guesthouse in La Mesa

4.98 out of 5 average rating, 250 reviews

La Mesa Suite

Mi mesa es su mesa, a beautiful newly built home in sunny La Mesa. Easy access to centrally located shopping center, SDSU and up and coming downtown La Mesa. Short drive down the 8 freeway to the mission beach and downtown SD. Includes everything you need in your home away from home while also providing comfort, security and privacy.

Dec 16 – 23

$143 per night