Guesthouse vacation rentals in San Diego

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Guest favorite
Guesthouse in Escondido
Hilltop cabin retreat with lake & mountain views
Rustic hilltop cabin overlooking Lake Hodges. Surrounded by open canyons & mountains, you will feel like you're a million miles away from everything as you take in the views from the cabin, deck or the outside shower, swim in the saltwater pool, or relax by the fire bowl. A short walk to lake with boating, fishing & miles of hiking/mountain biking trails. Property offers swimming pool, fire bowl, and shaded arbor. SD Zoo Safari Park, wineries, breweries, & ocean beaches all within easy reach.
Jul 17 – 24
$146 per night
4.92 out of 5 average rating, 620 reviews
Guest favorite
Guesthouse in San Diego
Romantic Private Garden Studio Near Downtown
A magical private garden surrounds a tiny studio (240 sq ft) with kitchenette in historic residential district, 10 blocks to East Village and Petco BallPark, near Gaslamp Quarter, and one mile to Convention Center and downtown. Easy access to freeways, very close to Balboa Park, San Diego Zoo, and Coronado Island. Airport and train station less than 15 min. We offer a safe, sweet, and contemplative getaway near the city, with WiFi but no TV. One pet OK only with prior approval. 420 friendly.
Nov 3 – 10
$104 per night
4.95 out of 5 average rating, 463 reviews
Guest favorite
Guesthouse in San Diego
Cozy guest studio with private deck
Cozy, small studio that is full of charm!!! Walking distance to amazing restaurants, and shops, but tucked away in a canyon, so you can also enjoy the peace. Guests will get to unwind on the private deck outdoors with the view of the canyon and fairy lights overhead. Or wake up with the complimentary coffee and enjoy the newly installed swivel tv. Our space is equipped with bathroom, A/C/heat, private deck, queen bed, bar fridge, microwave, tv and laundry.
Jan 13 – 20
$86 per night
4.9 out of 5 average rating, 720 reviews

Popular amenities for San Diego guesthouse rentals

Family-friendly guest house rentals

Guest favorite
Guesthouse in Bonita
Garden Cottage with a bathroom, Kitchenet & patio
Jun 10 – 17
$83 per night
4.93 out of 5 average rating, 296 reviews
Superhost
Guesthouse in San Diego
charming, colorful, close to beach
Oct 8 – 15
$90 per night
4.77 out of 5 average rating, 866 reviews
Superhost
Guesthouse in San Diego
$100-150 night--Windansea #3
Sep 26 – Oct 3
$131 per night
4.77 out of 5 average rating, 582 reviews
Guest favorite
Guesthouse in El Cajon
Fletcher Hills - modern 1 BR.Easy, no step access.
Oct 7 – 14
$90 per night
4.99 out of 5 average rating, 185 reviews
Guest favorite
Guesthouse in Chula Vista
Private Casita in Great Eastlake Neighborhood
May 14 – 21
$83 per night
4.95 out of 5 average rating, 464 reviews
Guest favorite
Guesthouse in San Diego
Your Kensington Bungalow
May 18 – 25
$111 per night
4.96 out of 5 average rating, 245 reviews
Guest favorite
Guesthouse in San Diego
Central & Serene Secret Garden Guesthouse
Aug 21 – 28
$120 per night
4.97 out of 5 average rating, 493 reviews
Guest favorite
Guesthouse in Oceanside
The Flying Mermaid
May 17 – 24
$77 per night
4.98 out of 5 average rating, 481 reviews
Guest favorite
Guesthouse in San Diego
North Park, San Diego's Best At Your Doorstep
Mar 28 – Apr 4
$135 per night
4.96 out of 5 average rating, 205 reviews
Guest favorite
Guesthouse in San Diego
Private Cottage in Walkable North Park w/AC
May 5 – 12
$104 per night
4.93 out of 5 average rating, 438 reviews
Guest favorite
Guesthouse in San Diego
Studio in the Heart of South Park!
Jul 5 – 12
$85 per night
4.8 out of 5 average rating, 419 reviews
Guest favorite
Guesthouse in San Diego
Modern Surf Cottage
Jan 30 – Feb 6
$186 per night
4.93 out of 5 average rating, 491 reviews

Guest house rentals with a patio

Guest favorite
Guesthouse in San Diego
Private Studio Cottage with Outdoor Patio
Oct 28 – Nov 4
$150 per night
4.98 out of 5 average rating, 112 reviews
Guest favorite
Guesthouse in San Diego
Central studio w/ private outdoor space & parking
Nov 13 – 20
$119 per night
4.93 out of 5 average rating, 135 reviews
Guest favorite
Guesthouse in La Mesa
La Mesa Suite
Jan 14 – 21
$137 per night
4.97 out of 5 average rating, 235 reviews
Guest favorite
Guesthouse in San Diego
Adorable cottage in Talmadge
Dec 9 – 16
$103 per night
4.99 out of 5 average rating, 144 reviews
Guest favorite
Guesthouse in La Mesa
Da Hui Hut-Beachy home/La Mesa’s best view and spa
May 19 – 26
$156 per night
4.98 out of 5 average rating, 120 reviews
Guest favorite
Guesthouse in San Diego
*Heart of SD* Zoo Nearby * Private Patio* Central*
May 15 – 22
$122 per night
4.9 out of 5 average rating, 160 reviews
Guest favorite
Guesthouse in San Diego
Modern Guest House with pool, steps to SDSU
Aug 16 – 23
$104 per night
4.92 out of 5 average rating, 112 reviews
Guest favorite
Guesthouse in La Mesa
SDCannaBnB #1 *420 *parking *dog-friendly *hot tub
May 20 – 27
$130 per night
4.99 out of 5 average rating, 151 reviews
Guest favorite
Guesthouse in Poway
⭐️Garden studio guesthouse, resort living with pool
May 12 – 19
$140 per night
4.99 out of 5 average rating, 113 reviews
Guest favorite
Guesthouse in Oceanside
Detached, Private Cottage! Fenced, PET friendly!
Nov 18 – 25
$115 per night
4.94 out of 5 average rating, 143 reviews
Superhost
Guesthouse in San Diego
City Cottage-New Detached Suite FreeJacuzzi & Gym
May 6 – 13
$128 per night
4.83 out of 5 average rating, 122 reviews
Guest favorite
Guesthouse in San Diego
Private, beautiful 1-bedroom 2 story guest house
Apr 8 – 15
$91 per night
4.85 out of 5 average rating, 119 reviews

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in San Diego
Sparkling Clean Plush Studio w/Private Patio & AC
May 3 – 10
$117 per night
4.91 out of 5 average rating, 163 reviews
Guest favorite
Guesthouse in San Diego
Carrie’s North Park Casita, in Heart of San Diego
Jun 11 – 18
$136 per night
4.99 out of 5 average rating, 126 reviews
Guest favorite
Guesthouse in San Diego
Waterhaven - A Pondside Oasis
Oct 8 – 15
$205 per night
5.0 out of 5 average rating, 451 reviews
Guest favorite
Guesthouse in San Diego
Casita Hermosa - Close to everything in San Diego
Aug 22 – 29
$155 per night
4.99 out of 5 average rating, 112 reviews
Guest favorite
Guesthouse in San Diego
The Coziest Retreat in N. PB
May 25 – Jun 1
$204 per night
4.97 out of 5 average rating, 244 reviews
Guest favorite
Guesthouse in San Diego
Charming Granny Flat Near SDSU & Transit Center
Apr 11 – 18
$90 per night
4.91 out of 5 average rating, 110 reviews
Superhost
Guesthouse in San Diego
Pacific Beach Cottage Blocks from Beaches/La Jolla
Nov 10 – 17
$187 per night
4.82 out of 5 average rating, 211 reviews
Guest favorite
Guesthouse in San Diego
The Golden Hill mosaic "casita"
May 15 – 22
$116 per night
4.87 out of 5 average rating, 398 reviews
Guest favorite
Guesthouse in San Diego
North Park Garden Retreat Casita
May 16 – 23
$104 per night
4.98 out of 5 average rating, 175 reviews
Guest favorite
Guesthouse in San Diego
New Guest House - North Park
Dec 12 – 19
$170 per night
4.98 out of 5 average rating, 152 reviews
Guest favorite
Guesthouse in San Diego
Private beach guesthouse w/ private parking
Jul 1 – 8
$180 per night
4.97 out of 5 average rating, 194 reviews
Guest favorite
Guesthouse in San Diego
The Best Cottage in North Park!
Aug 14 – 21
$106 per night
4.92 out of 5 average rating, 513 reviews

Quick stats about guesthouse rentals in San Diego

Total rentals

1K properties

Rentals with dedicated workspaces

540 properties have a dedicated workspace

Rentals with a pool

90 properties have a pool

Pet-friendly rentals

240 properties allow pets

Family-friendly rentals

130 properties are a good fit for families

Total number of reviews

102K reviews

Destinations to explore