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Vacation rentals in Mesilla

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Top-rated vacation rentals in Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite
Guesthouse in Las Cruces
Ocotillo Casita in Historic Mesilla
We've created a vision for this property with renovated 90-year-old historic structures to create sustainable, environmental friendly spaces with rainwater harvesting, solar energy, electric solar-powered car charger. This renovated adobe casita is the 2nd structure after our main house. The 3rd is a smaller rental called Yucca Casita. We are within 2 blocks of the historic Mesilla plaza with its farmers market, shops, galleries, restaurants, and walking trails along historic acequias (canals).
Aug 18 – 25
$92 per night
5.0 out of 5 average rating, 173 reviews
Guest favorite
Home in Las Cruces
Charming Adobe One Block from the Mesilla Plaza
Beautiful, private casita built in the 1930's one block from the plaza. Historic charm with modern conveniences. Perfect for quiet retreat. Fenced flagstone patio in back yard fully equipped with gas grill, outdoor fireplace, outdoor dining area and french doors opening from the house. Large front yard fully enclosed. Full front porch creates shade for chair. This house is peaceful but just steps from the fiestas and activities on the historical Mesilla Plaza.
Oct 18 – 25
$91 per night
4.96 out of 5 average rating, 137 reviews
Guest favorite
Home in Mesilla
Shadow of the Valley in Historic Mesilla
Sombra Del Valle is a beautiful home located in a quiet neighborhood and within 5 minute walking distance to the historic Mesilla plaza and 2 minute walking distance to a Brewery and restaurant and approximately 5 minute drive to NMSU. The home is comfortable and spacious; great for family trips, honeymoons, or just a fun getaway. There is free guest private parking. Once you stay here you will want to come back; it’s a home away from home.
Nov 3 – 10
$174 per night
4.99 out of 5 average rating, 136 reviews

Popular amenities for Mesilla vacation rentals

Stay near Mesilla's top sights

La Posta De Mesilla73 locals recommend
Mesilla Plaza20 locals recommend
Cracker Barrel Old Country Store4 locals recommend
Andele Restaurant44 locals recommend
Andele's Dog House27 locals recommend
Basilica of San Albino3 locals recommend

Other great vacation rentals in Mesilla

Guest favorite
Home in Las Cruces
Hacienda Shay
May 25 – Jun 1
$131 per night
4.81 out of 5 average rating, 155 reviews
Guest favorite
Guesthouse in Las Cruces
Getaway Guesthouse in Historic Mesilla
May 7 – 14
$116 per night
4.96 out of 5 average rating, 219 reviews
Guest favorite
Guesthouse in La Mesa
Charming Casita with Patio & Hottub
Apr 30 – May 7
$88 per night
4.97 out of 5 average rating, 1120 reviews
Guest favorite
Apartment in Las Cruces
Condo Near Mesilla Plaza, NMSU & Fine Restaurants
Mar 29 – Apr 5
$104 per night
4.94 out of 5 average rating, 140 reviews
Guest favorite
Home in Mesilla
Casa Del Sol-near Las Cruces
May 8 – 15
$94 per night
4.97 out of 5 average rating, 176 reviews
Guest favorite
Guesthouse in Las Cruces
Cozy Casita w/private patio near Old Mesilla
Apr 26 – May 3
$70 per night
4.97 out of 5 average rating, 178 reviews
Guest favorite
Apartment in Las Cruces
Enchanted Villas #3
Jun 21 – 28
$71 per night
4.93 out of 5 average rating, 115 reviews
Guest favorite
Guesthouse in Las Cruces
Studio Casita kids and dogs welcome!
Apr 30 – May 7
$56 per night
4.92 out of 5 average rating, 177 reviews
Guest favorite
Guesthouse in Las Cruces
Casa Elena Adobe casita in historic Mesilla
Aug 16 – 23
$75 per night
4.93 out of 5 average rating, 74 reviews
Guest favorite
Townhouse in Mesilla
Modern Townhome in Quiet Mesilla
Jun 19 – 26
$76 per night
4.89 out of 5 average rating, 65 reviews
Guest favorite
Home in Las Cruces
Cottage Noz
Nov 17 – 24
$84 per night
4.97 out of 5 average rating, 34 reviews
Guest favorite
Condo in Las Cruces
Sancho's Condo De Mesilla
Feb 1 – 8
$86 per night
5.0 out of 5 average rating, 18 reviews

Quick stats about vacation rentals in Mesilla

Total rentals

70 properties

Rentals with a pool

20 properties have a pool

Pet-friendly rentals

30 properties allow pets

Family-friendly rentals

40 properties are a good fit for families

Total number of reviews

6.8K reviews

Nightly prices starting at

$50 before taxes and fees

Destinations to explore

  1. Airbnb
  2. United States
  3. New Mexico
  4. Doña Ana County
  5. Mesilla