House vacation rentals in DeSoto County

Find and book unique houses on Airbnb

Top-rated house rentals in DeSoto County

Guests agree: these houses are highly rated for location, cleanliness, and more.

Guest favorite
Home in Hernando
Hernando Hideaway (Entire Lakehouse)
Enjoy our 2000 sq ft lake house in a private peaceful community with panoramic views of the lake. We are a licensed BNB with DeSoto County and the State of Mississippi until the year 2035. (Lic # 20110070) You will have the entire lake house to yourself and we provide coffee and pastries for breakfast. We are 15 minutes from Tunica Expo, 5 minutes to Tunica National Golf Course, 10 Minutes to the casinos; 38 minutes to Beale St, Bass Pro Shop, Peabody Hotel, Graceland and The Lorraine Hotel.
Feb 2 – 9
$180 per night
4.92 out of 5 average rating, 203 reviews
Guest favorite
Home in Southaven
Near Memphis, TN Mi Casa Es Su Casa
CLOSE TO MEMPHIS, TN 10 MINUTES AWAY VERY big house!! Walk-in closets. A 26X21 area with a pool table, playing card table, plenty of room for kids to play, entertain OR hang out. Front porch to enjoy the nights AND back porch to have your cookout. Driveway for several vehicles. Two homes on the property, rented separately. Like in the country BUT in the city. Tranquil, Safe, Close to shopping areas, gas stations, close to highways. Close to Snowden Grove. Very close to Memphis, TN
Jul 19 – 26
$271 per night
4.81 out of 5 average rating, 139 reviews
Guest favorite
Home in Southaven
The Country Cottage
Escape to the tranquility of our charming country cottage in Southaven, MS! Nestled on private farmland, this hidden gem offers the perfect retreat. Enjoy the best of both worlds with a serene countryside setting and easy access to modern amenities. Only a 5-10 minute drive away, you'll find the Landers Center for events, the Tanger Outlet Mall for shopping, and quick access to Interstate 55 for your convenience. Book your stay today and create lasting memories at our Southaven oasis.
Mar 25 – Apr 1
$128 per night
4.94 out of 5 average rating, 16 reviews

Popular amenities for DeSoto County house rentals

House rentals with a pool

Guest favorite
Home in Memphis
Family Friendly home near Graceland
Apr 9 – 16
$148 per night
4.87 out of 5 average rating, 249 reviews
Guest favorite
Home in Memphis
Heated Pool Mid-Century Oasis | Playground + 75"TV
Aug 14 – 21
$646 per night
4.95 out of 5 average rating, 136 reviews
Guest favorite
Home in Memphis
Brand new stylish Memphis Mother in law apartment
Oct 11 – 18
$65 per night
4.85 out of 5 average rating, 165 reviews
Superhost
Home in Memphis
Spacious renovated house!
Oct 27 – Nov 3
$366 per night
4.78 out of 5 average rating, 102 reviews
Guest favorite
Home in Memphis
Memphis Outskirts, Safe, Private, Quiet Guesthouse
Aug 13 – 20
$135 per night
5.0 out of 5 average rating, 53 reviews
Guest favorite
Home in Southaven
Cori's Pool House
Jun 8 – 15
$223 per night
5.0 out of 5 average rating, 22 reviews
Superhost
Home in Southaven
Spacious Southaven Home on 8 Acres w/ Private Pool
Jul 30 – Aug 6
$496 per night
4.75 out of 5 average rating, 72 reviews
Guest favorite
Home in Senatobia
Gorgeous Park-like Oasis 4 acres w/ Stunning Pool
Jan 24 – 31
$478 per night
4.92 out of 5 average rating, 24 reviews
Guest favorite
Home in Memphis
Vacation Destination-sauna/hot tub/5 full baths!
Oct 19 – 26
$665 per night
5.0 out of 5 average rating, 13 reviews
Guest favorite
Home in Memphis
4 bedroom home with pool
Jun 9 – 16
$429 per night
4.94 out of 5 average rating, 17 reviews
Guest favorite
Home in Walls
Cozy Farmhouse Retreat with KING Master Suite
May 23 – 30
$325 per night
5.0 out of 5 average rating, 24 reviews
Guest favorite
Home in Memphis
Heart of Memphis, A gift from Elvis to his doctor.
Oct 28 – Nov 4
$750 per night
4.88 out of 5 average rating, 86 reviews

Weekly house rentals

Superhost
Home in Southaven
Townhouse near by everything! 10% off at my salon!
Jun 30 – Jul 7
$112 per night
4.79 out of 5 average rating, 14 reviews
Guest favorite
Home in Southaven
Large Groups & Special Events!
Nov 18 – 25
$545 per night
4.88 out of 5 average rating, 17 reviews
Guest favorite
Home in Horn Lake
Luxury 3 bedroom ranch with upstairs bonus
Jan 2 – 9
$221 per night
4.91 out of 5 average rating, 32 reviews
Guest favorite
Home in Southaven
KING Bed -Spacious Hidden Gem!
Apr 5 – 12
$230 per night
4.95 out of 5 average rating, 37 reviews
Guest favorite
Home in Olive Branch
Cozy home just outside of Memphis
May 28 – Jun 4
$150 per night
4.91 out of 5 average rating, 33 reviews
Guest favorite
Home in Southaven
Styled, cozy residential retreat near town center
Jun 4 – 11
$322 per night
4.9 out of 5 average rating, 29 reviews
Guest favorite
Home in Southaven
MJ's Home Away From Home
Mar 23 – 30
$122 per night
4.93 out of 5 average rating, 14 reviews
Superhost
Home in Walls
Stylish & Cozy home to relax
Sep 25 – Oct 2
$173 per night
4.79 out of 5 average rating, 14 reviews
Superhost
Home in Horseshoe Lake
The Hideaway at Horseshoe Lake
Oct 6 – 13
$161 per night
4.78 out of 5 average rating, 74 reviews
Superhost
Home in Southaven
Quiet and Cozy Home in the Heart of Southaven
Feb 12 – 19
$134 per night
4.69 out of 5 average rating, 13 reviews
Superhost
Home in Horn Lake
4- Bedroom Haven for Relaxation
Jan 27 – Feb 3
$176 per night
4.84 out of 5 average rating, 19 reviews
Guest favorite
Home in Memphis
Charming Memphis Home
Apr 22 – 29
$174 per night
4.84 out of 5 average rating, 187 reviews

Private house rentals

Home in Hernando
Hernando 2 Bed/2Bath
Sep 19 – 26
$123 per night
4.59 out of 5 average rating, 29 reviews
Home in Olive Branch
3 bedroom house in olive branch large fenced yard
Mar 17 – 24
$128 per night
4.75 out of 5 average rating, 4 reviews
Guest favorite
Home in Southaven
4 Bedroom Home in the heart of Snowden District
Aug 10 – 17
$197 per night
4.75 out of 5 average rating, 12 reviews
Home in Southaven
Spacious 5 bedroom house, close to Snowden Grove
Oct 22 – 29
$277 per night
4.63 out of 5 average rating, 243 reviews
Home in Olive Branch
Great Home in Quiet Olive Branch #869
Nov 15 – 22
$330 per night
4.6 out of 5 average rating, 10 reviews
Guest favorite
Home in Southaven
Your Home 2
Nov 28 – Dec 5
$152 per night
4.87 out of 5 average rating, 31 reviews
Home in Olive Branch
Beautiful New Home! 1 Minute from Memphis
Oct 14 – 21
$226 per night
4.77 out of 5 average rating, 61 reviews
Guest favorite
Home in Olive Branch
ENTIRE HOME LESS THAN 1 MIN FROM MEMPHIS
Feb 11 – 18
$269 per night
5.0 out of 5 average rating, 21 reviews
Guest favorite
Home in Memphis
COZY meet LUX in the Suburbs and Ambience begins!
Jan 3 – 10
$158 per night
4.91 out of 5 average rating, 11 reviews
Home in Olive Branch
Magnolia Station
Jun 1 – 8
$158 per night
New place to stay
Home in Southaven
Home Away From Home
Nov 10 – 17
$110 per night
New place to stay
Home in Horn Lake
The home away from home
Jun 13 – 20
$147 per night
5.0 out of 5 average rating, 3 reviews

Destinations to explore