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Cape Girardeau vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

Top-rated vacation rentals in Cape Girardeau

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Superhost
Apartment in Cape Girardeau
Beautiful Historic Boulevard District Apartment
This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.
$90 per night
Superhost
Apartment in Cape Girardeau
Unique Design | Walk Downtown/River | .5 mile SEMO
At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.
$92 per night
Superhost
Loft in Cape Girardeau
Riverwalk Loft 3
Historical building with modern amenities. We are located right in the middle of downtown life. With the excitement there will come noise from bars, live bands, and the occasional train. If you love staying where fun is happening, this ones for you. Please note: we are located above an arcade bar and you are a building up from the River wall. There is also a currently operational TRAIN track with TRAINS, that make TRAIN noises 200ft from our lofts.
$160 per night

Stay near Cape Girardeau's top sights

Capaha Park4 locals recommend
Katy O'Ferrell's Publick House9 locals recommend
Port Cape13 locals recommend
Dogwood Social House3 locals recommend
Mary Jane bourbon + smokehouse7 locals recommend
Pilot House Restaurant & Catering3 locals recommend

Other great vacation rentals in Cape Girardeau

Superhost
Cottage in Cape Girardeau
The Candle Cottage in downtown Cape.
$119 per night
Superhost
Guesthouse in Cape Girardeau
Downtown Guesthouse- Romantic Getaway
$102 per night
Superhost
Cabin in Cape Girardeau
Log Cabin w/ Hot tub - Near Casino & Downtown Cape
$121 per night
Superhost
Guest suite in Cape Girardeau
Downtown loft, walk to all the action, charming
$115 per night
Superhost
Apartment in Cape Girardeau
Brand new 2 bedroom unit right in downtown Cape.
$129 per night
Superhost
Home in Cape Girardeau
Escape to DOWNTOWN CAPE! Entire House!
$100 per night
Superhost
Home in Jackson
The Rusty Owl-A Charming Victorian Dwelling
$98 per night
Superhost
Cottage in Cape Girardeau
Historic Cottage Walkable to Downtown Cape
$146 per night
Superhost
Home in Cape Girardeau
The Hamilton House
$102 per night
Superhost
Home in Cape Girardeau
Ace Of Hearts- 1 Bed 1 Bath
$150 per night
Superhost
Guest suite in Cape Girardeau
Cape Comfy! Close to SEMO & Capaha! CLEAN! 5 Star!
$54 per night
Superhost
Apartment in Cape Girardeau
Historical Kage House
$144 per night

Quick stats about vacation rentals in Cape Girardeau

Total rentals

120 properties

Rentals with dedicated workspaces

70 properties have a dedicated workspace

Pet-friendly rentals

30 properties allow pets

Family-friendly rentals

50 properties are a good fit for families

Total number of reviews

7.2K reviews

Nightly prices starting at

$20 before taxes and fees

Destinations to explore