Cape Girardeau vacation rentals

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Top-rated vacation rentals in Cape Girardeau

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Guest favorite
Loft in Perryville
Downtown Loft Amazing Bath Tub & Shower
Downtown Perryville, MO **DISCLAIMER** you will hear restaurant chatter & music if you do not have a tv/or radio playing between the hours of 10:30am & 1:30am. If you go to bed early I recommend headphones, ear plugs or play nature sounds on Alexa. This is a pet friendly loft apartment so I would not recommend if you are allergic to dogs or cats. This apartment is located above one of the most popular destination restaurant's around "Mary Jane Burgers & Brew" on the Downtown Historic Square.
Dec 10 – 17
$122 per night
4.98 out of 5 average rating, 265 reviews
Guest favorite
Apartment in Cape Girardeau
Beautiful Historic Boulevard District Apartment
This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.
Aug 21 – 28
$92 per night
4.97 out of 5 average rating, 344 reviews
Guest favorite
Home in Jackson
The Rusty Owl-A Charming Victorian Dwelling
The Rusty Owl is a peaceful place with easy access to I-55. House has high speed (300 up and down) wifi. Jackson: Check out Flickerwood Arena, (9 minutes away... for ATV and barrel racing; horse shows and rodeos) Jackson History Center: Free. Open daily. Cape Girardeau: Live music and relaxation at The Library and 21 Taps. Hunter Valley Winery open weekends. 1 private lower level queen bedroom/ two private (1 queen, 1 twin) rooms and room with a antique full bed and a twin bed upstairs.
Aug 20 – 27
$103 per night
4.92 out of 5 average rating, 264 reviews

Popular amenities for Cape Girardeau vacation rentals

Stay near Cape Girardeau's top sights

Capaha Park4 locals recommend
Dogwood Social House3 locals recommend
Port Cape13 locals recommend

Other great vacation rentals in Cape Girardeau

Guest favorite
Place to stay in Cobden
Eva's Roost Retreat - Center For Lost Arts
Sep 4 – 11
$93 per night
4.95 out of 5 average rating, 267 reviews
Guest favorite
Home in Cape Girardeau
Escape to DOWNTOWN CAPE! Entire House!
May 2 – 9
$93 per night
4.92 out of 5 average rating, 161 reviews
Guest favorite
Loft in Perryville
June Bug’s Loft **NO CLEANING FEE**
Aug 25 – Sep 1
$72 per night
4.92 out of 5 average rating, 335 reviews
Superhost
Cabin in Alto Pass
Hutchins Creek Cabin -2br- Wine Trail & Wilderness
Nov 20 – 27
$119 per night
4.91 out of 5 average rating, 134 reviews
Guest favorite
Place to stay in Makanda
Maple Ridge Cabin at Panther’s Rest
Jul 23 – 30
$103 per night
4.93 out of 5 average rating, 153 reviews
Guest favorite
Farm stay in Fredericktown
NEW DC Farmhouse Come relax in our HOT JACUZZI
May 14 – 21
$106 per night
4.94 out of 5 average rating, 275 reviews
Guest favorite
Cabin in Alto Pass
Ma's Cabin, Alto Pass, IL. Fine country lodging.
Jul 13 – 20
$72 per night
4.99 out of 5 average rating, 207 reviews
Guest favorite
Cabin in Alto Pass
Bald Knob Cabin
Aug 9 – 16
$99 per night
5.0 out of 5 average rating, 109 reviews
Guest favorite
Apartment in Cape Girardeau
Private Downtown Apartment
Nov 9 – 16
$110 per night
4.97 out of 5 average rating, 59 reviews
Guest favorite
Treehouse in Cape Girardeau
Twisted Sassafras Treehouse
Dec 15 – 22
$213 per night
4.98 out of 5 average rating, 51 reviews
Guest favorite
Guesthouse in Cape Girardeau
Cozy 1-BR guest house w/free parking on premises
Sep 24 – Oct 1
$66 per night
4.94 out of 5 average rating, 54 reviews
Guest favorite
Cottage in Cape Girardeau
Country cottage with view of winding creek
Jul 4 – 11
$114 per night
4.91 out of 5 average rating, 74 reviews

Other great vacation rentals in Cape Girardeau

Guest favorite
Guest suite in Cape Girardeau
[*Charming Cozy Suite*]
Oct 4 – 11
$50 per night
4.86 out of 5 average rating, 56 reviews
Guest favorite
Home in Cape Girardeau
Cozy Cottage
Aug 21 – 28
$114 per night
4.95 out of 5 average rating, 38 reviews
Guest favorite
Tiny home in Jackson
The Cottage, Rusted Route Farms
Apr 1 – 6
$135 per night
5.0 out of 5 average rating, 13 reviews
Guest favorite
Apartment in Cape Girardeau
Historical Kage House
Dec 27 – Jan 3
$134 per night
4.97 out of 5 average rating, 73 reviews
Guest favorite
Loft in Cape Girardeau
Lorimier Loft Gallery next to SEMO River Campus
Apr 14 – 21
$137 per night
5.0 out of 5 average rating, 11 reviews
Superhost
Home in Cape Girardeau
Herman’s Cozy Corner
Jul 22 – 29
$91 per night
4.83 out of 5 average rating, 65 reviews
Guest favorite
Apartment in Cape Girardeau
Visit the "Gone Girl" neighborhood
Jul 18 – 25
$69 per night
4.89 out of 5 average rating, 88 reviews
Superhost
Home in Cape Girardeau
3 Bed Bungalow w/ Deck and Fenced-In Back Yard
Dec 28 – Jan 4
$88 per night
4.78 out of 5 average rating, 27 reviews
Guest favorite
Guesthouse in Cape Girardeau
Private two room suite in downtown Cape Girardeau
Apr 13 – 20
$85 per night
5.0 out of 5 average rating, 67 reviews
Guest favorite
Cottage in Cape Girardeau
Beautiful Sunset Cottage with amazing views
Aug 9 – 16
$364 per night
5.0 out of 5 average rating, 19 reviews
Guest favorite
Farm stay in Perryville
Kirn's Hummingbird Haven
Jan 13 – 20
$83 per night
5.0 out of 5 average rating, 53 reviews
Guest favorite
Loft in Marble Hill
Loft in the Ozark Foothills
Dec 2 – 9
$82 per night
4.9 out of 5 average rating, 58 reviews

Quick stats about vacation rentals in Cape Girardeau

Total rentals

140 properties

Rentals with dedicated workspaces

90 properties have a dedicated workspace

Pet-friendly rentals

40 properties allow pets

Family-friendly rentals

60 properties are a good fit for families

Total number of reviews

8K reviews

Nightly prices starting at

$20 before taxes and fees

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Cape Girardeau?

    Yes! Work meets play with ease at over 90 vacation rentals in Cape Girardeau featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there pet-friendly vacation rentals in Cape Girardeau?

    Four-legged friends are welcome in Cape Girardeau. Choose from more than 40 vacation rentals for guests traveling with pets.

  • Do apartment rentals in Cape Girardeau have wifi?

    Absolutely! We offer over 30 apartment rentals with wifi in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.

  • How much does it cost to stay in apartment rentals in Cape Girardeau?

    Experience the best of Cape Girardeau with our apartment rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there family-friendly house rentals in Cape Girardeau?

    Cape Girardeau has more than 40 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.

  • Do house rentals in Cape Girardeau have a bbq area?

    Absolutely! We offer over 10 house rentals with a bbq area in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Cape Girardeau have air conditioning?

    Absolutely! We offer over 70 house rentals with air conditioning in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.

  • What are the most popular amenities for Apartment Rentals in Cape Girardeau?

    Enhance your stay in our Apartment Rentals with the most popular amenities: over 30 homes with wifi, over 30 homes with air conditioning, and more. Indulge in the ultimate retreat, tailored to your preferences.

Destinations to explore