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House vacation rentals in Santa Cruz Department
Find and book unique houses on Airbnb
Top-rated house rentals in Santa Cruz Department
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santa Cruz Department house rentals
House rentals with a pool
![](https://a0.muscache.com/im/pictures/miso/Hosting-893392304879764988/original/2094d42b-9e3f-437e-91b9-00ea06d6e999.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
4.87 out of 5 average rating, 15 reviewsCozy condominium house
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1127577555191836416/original/4a646dc7-1030-4a4c-abfb-b53d2eee283e.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 7 reviewsVacation house with swimming pool
![](https://a0.muscache.com/im/pictures/hosting/Hosting-U3RheVN1cHBseUxpc3Rpbmc6MjY2MzE0NDM%3D/original/e5703356-8b01-494b-85da-0b88b1b8b4fb.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
4.71 out of 5 average rating, 17 reviews@Airbnb The House Of Don Lucho
![](https://a0.muscache.com/im/pictures/miso/Hosting-1101749479007622639/original/4901c665-1162-43d8-b1c9-0fa9c85ad01f.png?im_w=720)
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 3 reviewsHouse
![](https://a0.muscache.com/im/pictures/miso/Hosting-960015973197317935/original/62603dfe-0fd6-4856-9367-ee9b7701e0bb.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
4.8 out of 5 average rating, 35 reviewsBeach House in Santa Cruz
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Home in Santa Cruz de la Sierra
5 out of 5 average rating, 15 reviewsCHARMING RESIDENCE IN PRIVATE CLUB.
![](https://a0.muscache.com/im/pictures/miso/Hosting-642631730711594929/original/ba615e4d-6a67-4174-81e3-382923a2b017.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 14 reviewsCozy family home in private condo
![](https://a0.muscache.com/im/pictures/b722a9f6-281b-481f-ab16-b8e8456ac3d2.jpg?im_w=720)
Home in Buena Vista
5 out of 5 average rating, 5 reviewsCasa Pueblo
Weekly house rentals
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Home in Santa Cruz de la Sierra
4.75 out of 5 average rating, 4 reviewsBeautiful Cabin in Samaipata
![](https://a0.muscache.com/im/pictures/75048ab2-a830-4c21-a16f-442f0a54a839.jpg?im_w=720)
Home in Santa Cruz de la Sierra
4.67 out of 5 average rating, 3 reviewsComfortable and pleasant house within the 4th ring
![](https://a0.muscache.com/im/pictures/f754b7bb-3c5e-42bf-ae8a-11d73f769f2f.jpg?im_w=720)
Home in Santa Cruz de la Sierra
4.86 out of 5 average rating, 7 reviewsLA FELIPE. Home to enjoy.
![](https://a0.muscache.com/im/pictures/miso/Hosting-1130672036292656668/original/b76b8f06-ca03-460e-b391-c4b534945196.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
Casita Sirari
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1153484554998021860/original/fd74a361-d0b6-4e03-a51b-cb49597e7cfd.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
House Rental by day, week
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Home in Colinas del Urubó
New place to stayCasa en Santa Cruz
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1194269012660208256/original/92689c3c-a047-453b-b2bd-420bd6813762.jpeg?im_w=720)
Home in Provincia de Andrés Ibáñez
New place to stayLuxurious European Villa (private pool!)
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1181066717115285892/original/c105c2d7-4a47-455f-b1a7-3519ce4e69eb.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
New place to staySpacious and comfortable house with pool
Private house rentals
![](https://a0.muscache.com/im/pictures/miso/Hosting-1078431907005607562/original/9290926d-aca3-4f66-ae37-8e647bac7690.jpeg?im_w=720)
Home in Santiago de Chiquitos
Beautiful house in Santiago
![](https://a0.muscache.com/im/pictures/miso/Hosting-977678722648546795/original/7346b3be-a3ce-4b4b-b6d1-6e870e23fe0a.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
House in the Urubo with pool
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1183458048236473959/original/b30bc959-fc82-4b18-8f37-e817c4ddec3d.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
New place to stayFamily Home in Exclusive condo with Pools, Gym
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1202261662941439738/original/505b1d54-6da1-4cf5-9aae-eb90a0e81149.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
New place to stayBeautiful house in Comdominio
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1185620496913922818/original/46ea11ca-3c63-4a4a-abc1-68242efbd3d8.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
New place to stayfamily and central luxury home
![](https://a0.muscache.com/im/pictures/miso/Hosting-1188457726140991388/original/0e6e6101-ea1a-4045-9650-906f48b3a201.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
New place to stayCasa Quinta Las Palmas.
![](https://a0.muscache.com/im/pictures/88fe1521-9e94-4283-ad3d-2eac9ba42a81.jpg?im_w=720)
Home in Santa Cruz de la Sierra
The eastern house
![](https://a0.muscache.com/im/pictures/miso/Hosting-53842998/original/e97826d8-4f6a-4882-b7cc-0293fc9e2945.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
Nice house in a condominium with a pool, courts
Destinations to explore
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