Skip to content

Vacation rentals in Jefferson County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Jefferson County

Guests agree: these stays are highly rated for location, cleanliness, and more.

Home in Cadet
2BR House near Fyre Lake Winery with new Hot Tub!
This newly remodeled 2 bedroom house is an ideal choice for guests looking to explore the beauty of Bonne Terre, attend weddings and local events, or visit Fyre Lake Winery, which is only a mile away. You'll find two comfortable bedrooms - one with a king-size bed and the other with a full-size bed - providing a peaceful retreat after a day of adventure. Additionally, Bonne Terre Mines are conveniently located just 16 minutes away, making it a perfect spot to stay while exploring the area.
$100 per night
Cabin in Hillsboro
The Shagbark Hickory (Sauna & Hot Tub)
Take it easy at this unique and tranquil getaway. Enjoy a detox in our handcrafted sauna or soaking in the hot tub under a ton of stars! Full kitchen, bathroom w/ claw foot, & screened in porch. It’s very private, with land to explore. Take a stroll to the pond or creek or book a massage with our own licensed Massage therapist! 5 min to La Chance winery, 10 min to Desoto. 7 minutes to Big River access points, 10 min. to valley view glades, and 15 minutes to Washington state park.
$120 per night
Home in Dittmer
Honeymoon Suite Camp Skullbone In The Woods
Romantic quiet cozy chalet for two! Vintage décor with all the modern amenities of home. Relax inside to unwind, kick back and watch a movie, surf the web via free wi-fi, curl up with a good book, open up a board game for a friendly challenge or share a drink with that special someone. Want some fresh country air? Lace-up those hiking boots and take like Camp Skullbones. . Enjoy the stars on the intimate deck with the glow from the gas fire pit.
$129 per night

Other great vacation rentals in Jefferson County

Home in Barnhart
3 Bedroom Ranch By Grassy Field w/ Laundry & Deck
$109 per night
Home in Arnold
Mamaw's House
$90 per night
Home in Imperial
Grammy's Place~A Loving Home
$108 per night
Guesthouse in Barnhart
Rustic Secluded Guest House w/ Valley Views + Pool
$98 per night
Guesthouse in Imperial
The Greenhouse Inn
$170 per night
Cabin in Imperial
Serenity Log Inn - Log Out and Log Inn to Serenity
$98 per night
Home in De Soto
Lake Time! Dock and hot tub.
$200 per night
Home in Bloomsdale
Hop off the highway, Relax!
$78 per night
Cabin in Bonne Terre
Hand Built Log Cabin
$126 per night
Tiny home in Pacific
Route 66 railroad shanty, a cozy artsy small space
$102 per night
Private room in Imperial
ADA Compatible; Comfortable Studio South St. Louis
$97 per night
Treehouse in Dittmer
The Den at Dittmer Hollow
$153 per night

Other types of stays on Airbnb