Santee vacation rentals

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Top-rated vacation rentals in Santee

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Condo in Santee

4.98 out of 5 average rating, 49 reviews

Lovely Condo w/pool, balcony, and lakeside view!

Relax on the balcony overlooking the pool and lake Marion or go down and relax at the pool, or launch your boat at the boat ramp for the day and go fishing or cruising. There is also a myriad of golf courses near by. For dinner with a great view head over to the other side of the lake to the Lake House bar and grill for adult beverages on the lake with great food. For upscale dining Clark’s restaurant is a good choice. Bike,hike,or cook out over at Santee state park which is only 10 minutes away

Oct 30 – Nov 6

$138 per night

Guest favorite

Cottage in Sumter

4.96 out of 5 average rating, 369 reviews

Restful Lakeside Getaway Cottage -Dogs allowed.

This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

Nov 21 – 28

$99 per night

Guest favorite

Home in Sumter

4.96 out of 5 average rating, 110 reviews

The Corner Cottage

Location location! The "Corner Cottage" is a cozy home in the center of Sumter, right along a main street. Full of charm, this wee old house provides two stylish bedrooms, an office space, a like-new bathroom, and an updated kitchen. We are less than a mile from the beautiful Swan Lake Gardens, and shopping and dining are just around the corner. We're also not far from Shaw Airforce Base and the 95. Weary travellers welcomed! You won't find a more convenient home-base for your Sumter stay.

Sep 10 – 17

$85 per night

Guest favorite

Home in Santee

4.97 out of 5 average rating, 140 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Jul 3 – 10

$611 per night

Guest favorite

Cottage in Timmonsville

4.97 out of 5 average rating, 790 reviews

*Cottage Near Florence and I-95*

Located just 5 mins from I-95 (exit 153) and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, please). We offer king bed in master, 3 wall-mounted TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. Lock Box on front door for self-check-in! Come stay with us. 🙂

Oct 15 – 22

$114 per night

Guest favorite

Guesthouse in Florence

4.93 out of 5 average rating, 677 reviews

The Poolside Cottage: Close to Interstates

New floors and paint in January of 2023. Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, queen sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

Sep 29 – Oct 6

$92 per night

Guest favorite

Guest suite in Ehrhardt

4.95 out of 5 average rating, 155 reviews

Lazy Dog Acres Bridal Suite!

Relax by one of the 2 ponds with water features or on the patio. Take a walk around the pond with Isaac or Isabella (Great Danes)as your guide on our 13 acres. Sorry no pets allowed! There is a a micro, fridge & coffee mkr in ur suite. Cook your meal in our shared kitchen. All linens are sanitized w/ high temp sanitizing wash. You have your own private entrance so come and go as you please! Airbnb designated parking. I live on the 2nd floor should u need assistance !

Mar 1 – 8

$105 per night

Guest favorite

Cottage in Gaston

4.97 out of 5 average rating, 595 reviews

Congaree Vines - Woodland Cottage by a Vineyard!

Enjoy a Quiet Country Stay! This charming European style cottage is set by a Hobby Vineyard! Enjoy complimentary port wine from our vineyard, a fire pit and hammock under the stars! Congaree Vines also has the Log Cabin and Barn Bungalow. Pets are welcome at $25 per pet. If service dog, bring paperwork. We are near Congaree National Park, Columbia, USC, Ft. Jackson, Airport I-26 & Hwy 77. *15% off Guided Kayak in CNP w/Carolina Outdoor Adventures

Jun 14 – 21

$91 per night

Guest favorite

Home in Summerton

5.0 out of 5 average rating, 80 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Dec 13 – 20

$149 per night

Guest favorite

Cabin in Blackville

4.95 out of 5 average rating, 412 reviews

Weaver Woods & Cabin

We would like to share our cabin at the edge of the woods with you. We are truly in the country and you'll enjoy a quiet night far away from the city. The cows, chickens, and donkey will welcome you too. We also have a park area with a stream flowing through it for you to enjoy. I have a no pets policy inside the cabin. (Sorry, no exceptions). We do not rent the cabin out on a monthly basis. You may book a maximum of 10 days at a time.

May 24 – 31

$68 per night

Guest favorite

Home in Santee

5.0 out of 5 average rating, 21 reviews

Lakefront Lookout

The best panoramic views of Lake Marion! Whether you're out on the porch or indoors in our air-conditioned unit, you will not miss out on the beauty of the lake. Our updated kitchen is stocked with all the essentials for you to create your meals and cocktails. This is the place to hop on a boat, swim in the pool, fish, walk, run, or bike the pedestrian bridge, or just hang out with your company while watching the boats go by.

Dec 9 – 16

$166 per night

Guest favorite

Home in Summerton

4.97 out of 5 average rating, 111 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Gorgeous luxury log home directly on the big waters of Lake Marion with fishing pier/boat dock, brand new salt water pool, hot tub and much more! This custom home boasts 3 large bedrooms and a loft, two large bathrooms with double sinks, one with claw foot soaker tub and separate water closet. Huge screened in back porch for dining and entertainment with custom 12' outdoor bar. This home is 6 minutes from I-95.

Sep 30 – Oct 7

$553 per night