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Vacation rentals in Santa Isabel District

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Top-rated vacation rentals in Santa Isabel District

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Home in Corregimiento de Isla Grande

4.96 out of 5 average rating, 83 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Jun 22 – 29

$440 per night

Place to stay in Viento Frío

5.0 out of 5 average rating, 9 reviews

Caribbean Paradise, Preci Beach

Explora coral reefs and beaches, surrounded by palm trees and nature. Ideal for relaxing in a tranquil and beautiful setting. From June to November, enjoy snorkeling and boat rides. From December to April, relish the dry season with refreshing breezes and sunny days. In front of the house, an oceanic lagoon awaits, along with tropical trails and the rainforest just a few kilometers away. Our friendly hosts will take care of all your needs to ensure you have the best experience.

Aug 10 – 17

$384 per night
Guest favorite

Apartment in Juan Gallego

4.84 out of 5 average rating, 152 reviews

Pebos Reef, apt #1, Amazing location !

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Nov 13 – 20

$171 per night

Popular amenities for Santa Isabel District vacation rentals

Other great vacation rentals in Santa Isabel District

Home in La Guaira

4.73 out of 5 average rating, 22 reviews

Hermosa Casa Front on the Caribbean Sea, Juan Gallegos

May 25 – Jun 1

$200 per night

Home in La Guaira

5.0 out of 5 average rating, 3 reviews

Beach Houses in La Guayra, Juan Gallego.

May 28 – Jun 4

$191 per night

Boat in Garrote, Colón

4.75 out of 5 average rating, 4 reviews

Sailboat Playa Blanca, Mamei, Isla Grande, Linton

Jan 23 – 30

$80 per night

Cottage in Palenque, Colón

4.35 out of 5 average rating, 17 reviews

Beach House in front of the Caribean Sea.

Dec 25 – Jan 1

$73 per night

Cabin in Garrote

New place to stay

Cute harbor cabin with a/c and wifi

Jul 21 – 28

$43 per night

Villa in Palenque, Colón

4.48 out of 5 average rating, 21 reviews

Villa Blanca, Palenque

Jan 11 – 18

$411 per night

Home in Viento Frío

New place to stay

Beachfront rental in Panama, Viento Frío

Nov 21 – 28

$84 per night

Home in Garrote

Casita near Linton Bay Marina

Jul 1 – 6

$200 per night

Apartment in Garrote

4.33 out of 5 average rating, 6 reviews

Compact Caribbean Apartment "B"

Sep 5 – 12

$73 per night
Superhost

Nature lodge in Puerto Lindo

4.58 out of 5 average rating, 38 reviews

Hostel Wunderbar Atlantis Room

Dec 9 – 16

$39 per night

Place to stay in Garrote

4.75 out of 5 average rating, 4 reviews

Marine experience in Puerto Lindo, Colón

May 22 – 29

$85 per night
Guest favorite

Bed and breakfast in Garrote, Colón

5.0 out of 5 average rating, 7 reviews

Vista Caribe Gate of Heaven

May 30 – Jun 6

$99 per night