Skip to content

Vacation rentals in Murphysboro

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Murphysboro

Guests agree: these stays are highly rated for location, cleanliness, and more.

Lake front getaway for 2!
SUPERHOST
Entire rental unit · 2 guests · 1 bed · 1 bath
Lake front getaway for 2!Take it easy at this unique and tranquil getaway. Ideal for two people, this lake-front studio apartment is one within a four-plex, tucked away on a private drive in the countryside. This property is located on Old Highway 13 - between Murphysboro and Carbondale. You are right in the middle of many amenities and attractions sought after in the area - wineries, hiking, and SIU. A picnic table, charcoal grill, firepit, and string lights sets the outdoor space up nicely for a fun evening!
Creekside Valley: secluded spacious home for 8!
SUPERHOST
Entire residential home · 8 guests · 4 beds · 2 baths
Creekside Valley: secluded spacious home for 8!Remodeled in 2011 and completely renovated in 2019-2020, this home provides a rustic and modern feel while relaxing in the country side. Located along a creek bed, this property is within 10 miles of the Shawnee National Forest, with multiple wineries and hiking trails along the way. Being right outside the city limits of Murphysboro, known nationally for its BBQ, and a short drive from Carbondale and SIU (10-15 miles), you will be in an ideal area to see what Southern Illinois is all about!
Hilltop Retreat, a modernly-rustic getaway!
SUPERHOST
Entire residential home · 10 guests · 4 beds · 2 baths
Hilltop Retreat, a modernly-rustic getaway!At the top of the Shawnee Wine Trail, amidst the Shawnee National Forest, and tucked away in the country, is your next comfortable get-away from home. Located off the scenic highway, South 127, our newly renovated house atop Hillbilly Hill Trail, has everything you and up to 9 others would need in a guest home. Relax at the fire-pit in the private back yard with an uninhibited view of the sky, pasture, and private lake. Just pack a bag of clothes, your favorite food and drink, and come on over!

Vacation rentals for every style

Get the amount of space that is right for you

  • Homes
  • Hotels
  • Unique stays

Other great vacation rentals in Murphysboro

SUPERHOST
  1. Entire loft
  2. Murphysboro
The Guest House Loft
$66 per night
  1. Entire condominium (condo)
  2. Murphysboro
Lovely 2BedRm Condo. Sleeps 6. Washer/dryer aswell
$78 per night
SUPERHOST
  1. Entire residential home
  2. Murphysboro
Hot Tub/Walk to 17th St Bar & Grill/Microbrewery
$165 per night
  1. Campsite
  2. Murphysboro
Delightful 1 bedroom camper cozy in the outskirts.
$30 per night
SUPERHOST
  1. Entire cabin
  2. Murphysboro
Home Away From Home Shawnee Hills Wine Trail
$210 per night
  1. Entire condominium (condo)
  2. Murphysboro
Spacious 2BedRm w/1.5 bath & plenty of parking
$40 per night
  1. Entire residential home
  2. Murphysboro
Cozy 2 bedroom with large deck & fire pit
$125 per night
SUPERHOST
  1. Private room
  2. Murphysboro
Historic Hull House Inn Ms. Ella’s Chamber
$85 per night
SUPERHOST
  1. Entire residential home
  2. Murphysboro
Home Away From Home
$85 per night
SUPERHOST
  1. Entire residential home
  2. Murphysboro
SIU, Wine Trails, Home Away from Home West
$104 per night
SUPERHOST
  1. Entire residential home
  2. Murphysboro
Newly Renovated 3bed home w/ 2 car garage.
$80 per night
  1. Hotel room
  2. Carbondale
Comfy hotel room with all the essentials and more
$27 per night