Vacation rentals in Mission District, San Francisco

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Top-rated vacation rentals in Mission District, San Francisco

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Guest suite in Mission District

4.98 out of 5 average rating, 228 reviews

Mission Private 1BR/BA Garden Suite Separate Entry

Luxury garden suite w/ private entrance, private bathroom, and hot tub in one of SF's hottest neighborhoods - the Mission. No shared spaces in this quiet Inner Mission one-bedroom w/ large living room, Xfinity, Apple TV, hi-speed Wi-Fi. Lots of room to spread out & relax. Strict cleaning regimen incl 30-min UVC light treatment per room, min 24-hour vacancy, sterile wipe down of all common surfaces. Please check our location on map relative to places you plan to visit in SF. Please: no smoking.

Jun 20 – 25

$241 per night
Guest favorite

Guest suite in Potrero Hill

4.88 out of 5 average rating, 299 reviews

Take it Easy on Potrero Hill

Hidden on Potrero Hill is our lovely guest suite. Retreat to a bedroom: comfortable queen-bed in nook, work desk, and 2-seat couch. Full-bath, kitchenette, covered patio, amazing garden w panoramic views. Great location!! Walk to markets, restaurants, stages, cafes, bars, nightclubs, and parks...GORGEOUS VIEWS!! *DRIVE: 15 min-SFO, 30 min-OAK 10 min-Embarcadero/MOSCONE 6 min- GIANTS/Mission Bay/CHASE/Dogpatch *WALK: 5 min ZSFGH, THE MISSION *2-Level *1-2 Adults *1 Sweet Dog *3 nights minimum

Aug 23 – 30

$113 per night
Guest favorite

Guest suite in Bernal Heights

4.95 out of 5 average rating, 138 reviews

New Bernal Heights studio w/ Private Outdoor Space

Welcome to my modern studio with private entrance, walk-in closet, bathroom, kitchenette, and peaceful outdoor space with outdoor dining set, grill, and lounge chairs I am located on a quiet street in the Bernal Heights area and a 5min walk to Bernal Hill outdoor space, 20min walk to the shops, bars/restaurants on Cortland Avenue, 10min walk from Precita Park with local cafes, grocery store, & beautiful Park. It’s HILLY Note. kitchenette is outside the unit in private closed-off space in garage

Aug 12 – 19

$98 per night

Popular amenities for Mission District, San Francisco vacation rentals

Stay near Mission District, San Francisco's top sights

Mission District355 locals recommend
Potrero Center6 locals recommend
Farmhouse Kitchen Thai Cuisine117 locals recommend
Best Buy20 locals recommend
La Taqueria348 locals recommend
Balmy Alley124 locals recommend

Other great vacation rentals in Mission District, San Francisco

Guest favorite

Home in Mission District

4.96 out of 5 average rating, 107 reviews

Beautiful Victorian in the Heart of Mission

$568 per night
Guest favorite

Home in Potrero Hill

4.98 out of 5 average rating, 178 reviews

2br Victorian House with Breathtaking views

Jun 7 – 14

$344 per night
Guest favorite

Apartment in Castro

4.99 out of 5 average rating, 161 reviews

Luxury Studio 2 minutes from Magical Dolores Park

Dec 15 – 22

$203 per night
Guest favorite

Apartment in Bernal Heights

4.84 out of 5 average rating, 546 reviews

Grand and Cozy 1920's SF Studio

Dec 5 – 12

$127 per night
Guest favorite

Guest suite in Mission District

4.99 out of 5 average rating, 127 reviews

Large Light Filled Quiet Artist built 2BR Apt

Sep 14 – 21

$331 per night
Guest favorite

Guesthouse in Castro

4.97 out of 5 average rating, 272 reviews

Urban Oasis 1 bed 1bath - 1 block to Dolores Park

Nov 27 – Dec 4

$227 per night
Guest favorite

Apartment in San Francisco

4.98 out of 5 average rating, 225 reviews

View of Mission Dolores Church in a garden setting

May 22 – 29

$178 per night
Guest favorite

Guest suite in Bernal Heights

4.96 out of 5 average rating, 288 reviews

Entire private guest suite in beautiful Bernal.

Jun 11 – 18

$159 per night
Guest favorite

Apartment in Mission District

4.98 out of 5 average rating, 144 reviews

Grand Victorian, Family-Friendly w/ Hot Tub

Jul 20 – 27

$476 per night
Guest favorite

Guest suite in Noe Valley

4.91 out of 5 average rating, 446 reviews

Clipper Street Cottage

Jul 24 – 31

$149 per night
Guest favorite

Apartment in Potrero Hill

4.99 out of 5 average rating, 540 reviews

Hilltop Hideaway Light Filled Apartment Potrero

Jun 2 – 9

$187 per night
Guest favorite

Guesthouse in Excelsior

4.94 out of 5 average rating, 936 reviews

Immaculate studio space with free parking

Nov 11 – 18

$78 per night

Quick stats about vacation rentals in Mission District, San Francisco

Total rentals

1K properties

Rentals with dedicated workspaces

580 properties have a dedicated workspace

Rentals with a pool

50 properties have a pool

Pet-friendly rentals

200 properties allow pets

Family-friendly rentals

330 properties are a good fit for families

Total number of reviews

37K reviews

Destinations to explore