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Vacation rentals in Lake Santa Fe

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Top-rated vacation rentals in Lake Santa Fe

Guests agree: these stays are highly rated for location, cleanliness, and more.

SUPERHOST
  1. Entire home
  2. Melrose
Sante Fe Lakehouse with Canal for your Boat

Unplug and unwind on beautiful Lake Santa Fe! Enjoy your stay out on the dock while the wildlife flies by during an amazing sunset. This 5800 acre lake is considered the 3rd most stable lake in Florida and one of the clearest. Bring your Bass, Pontoon or Wake surf boat and keep them at the ready in our canal. This lake is also perfect for kayaking around the edge through the Bald Cypress trees.

$249 per night
SUPERHOST
  1. Entire rental unit
  2. Melrose
The Orchid of Lake Santa Fe

Melrose Bay on Lake Santa Fe This apartment is newly remodeled. It features new cabinets, new appliances, a private porch and lovely furnishings, WIFI and cable. Downtown Melrose is in walking distance with three restaurants (one is the famous Blue Water Bay), public library, post office, grocery store, dollar store and Ace. Bring your boat and launch at the nearby boat ramp. Lake Santa Fe is a recreational lake with clean spring fed water for swimming, boating, skiing and fishing.

$75 per night
SUPERHOST
  1. Entire rental unit
  2. Melrose
Lakefront Retreat Apartment Remodeled, Premium Bed

Private lake home on Big Lake Santa Fe is the perfect place to unwind and enjoy gorgeous sunset views. The rental unit is an upstairs separated apartment. It has a cedar interior with a cabin feel has recently been renovated with new appliances, flooring and updated bathroom with walk in shower. Bring your boat to cruise the lake or fish and tie up at our dock. Enjoy swimming, water skiing, fishing or just relaxing on the deck.

$90 per night

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Other great vacation rentals in Lake Santa Fe

SUPERHOST
  1. Private room
  2. Melrose
Bhakti House- Prvt Rm w 4 Beds & Prvt Bath
$35 per night
SUPERHOST
  1. Entire home
  2. Earleton
Lake House Escape & Play
$106 per night
SUPERHOST
  1. Entire cottage
  2. Melrose
The Nest on Lake Santa Fe in Melrose, FL
$140 per night
SUPERHOST
  1. Entire rental unit
  2. Waldo
Fernbank on beautiful Lake Alto. Laketime Getaway
$104 per night
SUPERHOST
  1. Private room
  2. Melrose
Bhakti House: Prvt 2BR Suite w Private Bath
$36 per night
SUPERHOST
  1. Entire townhouse
  2. Keystone Heights
3/2 Lake Geneva Getaway on Tranquility Cove
$140 per night
  1. Entire home
  2. Earleton
Home Nestled in Santa Fe Lake Trees, 19 Mi to UF
$141 per night
SUPERHOST
  1. Private room
  2. Keystone Heights
3 SWINGS
$75 per night
  1. Entire cabin
  2. Keystone Heights
Keystone Lake Front Cabin! Loaded with Amenities!
$61 per night
  1. Entire cabin
  2. Keystone Heights
Lake Hutchinson Home - BBQ & Firepit!
$139 per night
  1. Entire home
  2. Waldo
Gorgeous Waldo Home w/ New Dock on Santa Fe Lake!
$267 per night
  1. Entire cottage
  2. Keystone Heights
"Love Shack"
$83 per night
  1. Airbnb
  2. United States
  3. Florida
  4. Alachua County
  5. Lake Santa Fe