Colleton County vacation rentals

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Top-rated vacation rentals in Colleton County

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Guest favorite

Barn in Early Branch

5.0 out of 5 average rating, 101 reviews

Unique escape! 7 acres of woodsy paradise

Escape to Grays Inn - a peaceful and private setting located in the beautiful South Carolina Low Country! 7 acres all to yourself with woods surrounding the spacious yet cozy barndominium. Ideal for visiting hunters 🦌 , stargazers 💫 , tourists 📸 , golfers 🏌️‍♂️, or anyone desiring a peaceful escape🌲. Clean, newly renovated and furnished with unique decor. Secluded community not far from wildlife management areas, The Congaree Golf Club, and convenient enough for day trips to Low Country hotspots.

Nov 15 – 22

$93 per night
Guest favorite

Guest suite in Beaufort

4.96 out of 5 average rating, 505 reviews

Shady Rest #1 near historic downtown Beaufort

Nestled among oaks, this secure, private suite is attached to our home with a separate entrance. We're close to great views, restaurants and shopping, family-friendly activities, nightlife, and the beach. You’ll love our place because of the coziness, the views, and especially the location. It's about a mile from downtown Beaufort, adjacent to the Spanish Moss Biking and Hiking Trail, 6 miles from Parris Island MCRD, convenient to Hilton Head Island, and halfway between Charleston and Savannah.

Sep 21 – 28

$110 per night
Guest favorite

Guesthouse in Beaufort

4.96 out of 5 average rating, 206 reviews

Sunset River House

Our quaint little River House rests on the beautifully natural marsh grass banks of the Whale Branch River in a quiet rural neighborhood. It is located only 9 miles from Historic Downtown Beaufort and 15 miles from Parris Island Marine Corps Recruit Depot. Hunting Island State Park's sandy beaches, nature tails, and lighthouse tours are a scenic 40 minute drive away. You can swim, fish, kayak or go boating right from the dock in our own back yard. When you arrive; you won't want to leave!

Jan 19 – 26

$94 per night

Popular amenities for Colleton County vacation rentals

Other great vacation rentals in Colleton County

Guest favorite

Apartment in Beaufort

4.96 out of 5 average rating, 253 reviews

The Harrington - Historic Downtown Beaufort

Oct 21 – 28

$125 per night
Guest favorite

Farm stay in Ridgeland

4.97 out of 5 average rating, 427 reviews

Glamping on an off grid farm.

May 28 – Jun 4

$71 per night
Guest favorite

Home in Beaufort

4.9 out of 5 average rating, 120 reviews

Always Welcome-Downtown Beaufort

Nov 5 – 12

$111 per night
Guest favorite

Bungalow in Beaufort

4.97 out of 5 average rating, 155 reviews

Vintage Cottage near downtown Beaufort

Dec 6 – 13

$144 per night
Superhost

Bus in Hollywood

4.85 out of 5 average rating, 147 reviews

RETRO & FUN 1989 Skoolie Bus Luxury Experience

May 8 – 15

$80 per night
Guest favorite

Apartment in Summerville

4.91 out of 5 average rating, 148 reviews

Full Kitchen, 2 Bed, 2 Bath W/ Laundry & Fish Pond

Aug 30 – Sep 6

$143 per night
Guest favorite

Home in Beaufort

4.98 out of 5 average rating, 171 reviews

The Fiddler House - close to P.I. & Downtown Bft

Nov 2 – 9

$144 per night
Guest favorite

Guesthouse in Beaufort

4.94 out of 5 average rating, 227 reviews

Cozy private guest house

May 8 – 15

$90 per night
Guest favorite

Cottage in Beaufort

4.97 out of 5 average rating, 123 reviews

Peaceful River Retreat Near Historic District

Oct 9 – 16

$233 per night
Guest favorite

Condo in Edisto Island

4.91 out of 5 average rating, 119 reviews

422 Oristo Lodge

Nov 27 – Dec 4

$145 per night
Guest favorite

Cottage in Beaufort

4.97 out of 5 average rating, 219 reviews

Lovely Cottage in Beaufort w/ State Park Beach Pas

Sep 21 – 28

$210 per night
Guest favorite

Home in Beaufort

4.98 out of 5 average rating, 118 reviews

Restored 1889 Historic Cottage

Jan 2 – 9

$185 per night

Other great vacation rentals in Colleton County

Guest favorite

Home in Walterboro

5.0 out of 5 average rating, 45 reviews

The Cozy Casa

Jul 3 – 10

$196 per night
Guest favorite

Tiny home in Summerville

5.0 out of 5 average rating, 22 reviews

Country Cottage Retreat

Apr 12 – 19

$99 per night
Guest favorite

Tiny home in Beaufort

4.92 out of 5 average rating, 65 reviews

Cheerful tiny close to Parris Island & downtown

Nov 1 – 8

$91 per night
Guest favorite

Home in Summerville

5.0 out of 5 average rating, 31 reviews

Beautiful 2 Bedroom cottage in Summerville, SC

Oct 6 – 13

$74 per night
Guest favorite

Home in Summerville

4.97 out of 5 average rating, 31 reviews

Guest House/Villa

Jun 21 – 28

$104 per night
Guest favorite

Cottage in Dorchester County

4.81 out of 5 average rating, 16 reviews

Relaxing 2-bedroom cottage, Dorchester, S.C.

Sep 15 – 22

$115 per night
Guest favorite

Home in Branchville

4.93 out of 5 average rating, 28 reviews

Edisto River Turnhole Getaway

Oct 11 – 16

$150 per night
Guest favorite

Guesthouse in Seabrook

5.0 out of 5 average rating, 42 reviews

Adorable guesthouse outside Beaufort

Apr 15 – 22

$88 per night
Guest favorite

Guesthouse in Ridgeville

4.91 out of 5 average rating, 23 reviews

Cute Frog

Oct 13 – 20

$75 per night
Guest favorite

Home in Saint Helena Island

4.99 out of 5 average rating, 85 reviews

The Tidewatch: Beachfront Retreat on Harbor Island

Feb 11 – 18

$512 per night
Superhost

Cottage in Edisto Island

4.83 out of 5 average rating, 80 reviews

Escape to Edisto on the Creek

Sep 4 – 11

$113 per night
Superhost

Home in Ridgeland

4.88 out of 5 average rating, 51 reviews

Beautiful Coastal Cottage Hideaway - entire home

Jul 26 – Aug 2

$139 per night

Destinations to explore