Skip to content

Vacation rentals in Clayton

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Clayton

Guests agree: these stays are highly rated for location, cleanliness, and more.

Rental unit in Clayton
Charmingly Historic King Suite in Downtown Clayton
New King Bed Suite is just near your city favorites for when you don't want to stay in downtown St. Louis. Downtown Clayton is very peaceful, family-friendly, and is the center for artistic expression! This is a destination where people, businesses, and the arts thrive. Whether you are visiting for work or vacation, we are committed to giving you a luxurious experience. 24/7 virtual assistance! 🚕3 min-Shaw Park 🚕11 min-St. Louis Lambert Airport 🚕12 min-Science Center 🚕18 min-Busch Stadium
$154 per night
Rental unit in Clayton
Updated Clayton pied-à-terre with Old World charm
Bright and spacious, renovated Clayton condo is a perfect retreat for your St. Louis get-away! Large floor plan includes multipurpose great room incorporating lounge with remote-controlled gas fireplace, study, and reading area, updated kitchen with granite countertops and high-end appliances, modern bathroom with large walk-in shower and quaint accents and modern amenities, including washer/dryer, dishwasher, hardwood floors, arched doorways, antique stained glass windows, and high ceilings.
$121 per night
Serviced apartment in St. Louis
Dogtown Eats-Forest Park Walks-King Bed Rest (510)
Enjoy your stay in one of our corporate housing suites! Great location for anyone looking to stay in town for short or long-term periods of time! Fully equipped with all of your basic amenities and a few extras! We proudly boast a comfortable and enjoyable stay, all in the heart of the historic St Louis neighborhood, Dogtown! Great for anyone who wants to be located close to: - Barnes Jewish Hospital - SLU - Wash U - The Zoo - Nightlife - Great food - Downtown festivities and so much more!
$128 per night

Stay near Clayton's top sights

Photo of The Delmar Loop
The Delmar Loop46 locals recommend
Photo of St. Louis Galleria
St. Louis Galleria147 locals recommend
Photo of Blueberry Hill
Blueberry Hill73 locals recommend
Photo of Washington University in St. Louis
Washington University in St. Louis34 locals recommend
Photo of Shaw Park
Shaw Park13 locals recommend
Photo of Fitz's
Fitz's48 locals recommend

Other great vacation rentals in Clayton

Rental unit in Clayton
1920's 2 Bedroom 1 Bath - Clayton (1W)
$126 per night
Rental unit in Clayton
Luxe Sky Views & Park *Kg Bed, Workspace, Gym, W/D
$185 per night
Rental unit in Clayton
2 Bedroom 1 Bathroom - Hardwood Flrs Apt-1920's
$130 per night
Home in Clayton
Cheerful Demun 3 bedroom cottage w/ parking
$129 per night
Rental unit in Central West End
Cozy Central West End Condo
$76 per night
Rental unit in Clayton
Light and Bright 2 Bathroom 1 Bathroom Apt-1920's
$130 per night
Rental unit in The Hill
Explore The Hill on Foot from Chic Italian Studio
$77 per night
Rental unit in St. Louis
Albert Hall in the heart Delmar Loop Renovated
$86 per night
Rental unit in Clayton
1920's rehab 2 Bedroom 1 Bath APT Clayton (AL2W)
$125 per night
Rental unit in Central West End
Relaxing condo with parking CWE
$80 per night
Guesthouse in Maplewood
Weaver Guest House
$99 per night
Private room in University City
Upstairs Private fullbed room near Delmar loop/中国城
$31 per night
  1. Airbnb
  2. United States
  3. Missouri
  4. St. Louis County
  5. Clayton